Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.
about
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleusNeurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.A neuronal function of the tumor suppressor protein merlinNuclear export of proteins and drug resistance in cancerDystroglycan versatility in cell adhesion: a tale of multiple motifs.Oncogenic role of Merlin/NF2 in glioblastoma.Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastomaGene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.Cell cycle dependent association of EBP50 with protein phosphatase 2A in endothelial cellsInhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsA functional association between merlin and HEI10, a cell cycle regulator.Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.Phospho-proteomic immune analysis by flow cytometry: from mechanism to translational medicine at the single-cell level.Cytokinesis, ploidy and aneuploidy.Schwannomas and their pathogenesis.Molecular insights into NF2/Merlin tumor suppressor function.Scaffolding during the cell cycle by A-kinase anchoring proteins.Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression.Merlin sumoylation is required for its tumor suppressor activity.Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma.p53 performs an essential role in mediating the oncogenic stimulus triggered by loss of expression of neurofibromatosis type 2 during in vitro tumor progression.Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activityThe actin-binding ERM protein Moesin directly regulates spindle assembly and function during mitosis.Essential signaling in NF2 loss-related tumours: the therapeutic potential of CRL4DCAF1 and mTOR combined inhibition.
P2860
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P2860
Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Cell cycle-dependent nucleocyt ...... is 2 tumour suppressor merlin.
@en
type
label
Cell cycle-dependent nucleocyt ...... is 2 tumour suppressor merlin.
@en
prefLabel
Cell cycle-dependent nucleocyt ...... is 2 tumour suppressor merlin.
@en
P2860
P50
P356
P1433
P1476
Cell cycle-dependent nucleocyt ...... sis 2 tumour suppressor merlin
@en
P2093
Olli Carpén
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208283
P407
P577
2005-02-01T00:00:00Z
P5875
P6179
1044427739