Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
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Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastomaHairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding siteRegulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotypeBrain lipid-binding protein is a direct target of Notch signaling in radial glial cellsBiological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspectiveNotch Signaling in Neuroendocrine TumorsGlycosylated Notch and CancerNot so Fast: Co-Requirements for Sonic Hedgehog Induced Brain TumorigenesisTargeting the Notch signaling pathway in cancer therapeuticsFrom fly wings to targeted cancer therapies: a centennial for notch signalingNotch receptor expression in neurogenic regions of the adult zebrafish brainMiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastomaMicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastomaCerebellum development and medulloblastomaDevelopment and cancer of the cerebellumFBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastomaThe extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney developmentNotch inhibitors as a new tool in the war on cancer: a pathway to watch.Notch inhibition as a promising new approach to cancer therapy.MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes.Notch-1 regulates transcription of the epidermal growth factor receptor through p53.Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer.Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate.Loss of NOTCH2 positively predicts survival in subgroups of human glial brain tumorsMusashi1 modulates cell proliferation genes in the medulloblastoma cell line DaoyNOTCH2 is neither rearranged nor mutated in t(1;19) positive oligodendrogliomas.RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells.Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin.NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancerIdentification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.Notch signaling in glioblastoma: a developmental drug target?Autoregressive higher-order hidden Markov models: exploiting local chromosomal dependencies in the analysis of tumor expression profiles.Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells.Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenograftsInhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signatureSonic hedgehog acts as a negative regulator of {beta}-catenin signaling in the adult tongue epithelium.Notch signaling is not essential in sonic hedgehog-activated medulloblastoma.
P2860
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P2860
Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
@en
type
label
Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
@en
prefLabel
Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
@en
P2093
P1433
P1476
Notch1 and notch2 have opposite effects on embryonal brain tumor growth.
@en
P2093
Daniel J Brat
Douglas Ball
Ihab Elhassan
Irina Mikolaenko
Xingzhi Ni
Yunyue Wang
P304
P356
10.1158/0008-5472.CAN-04-1446
P407
P577
2004-11-01T00:00:00Z