The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
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Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen SpeciesBioavailability of Glucosinolates and Their Breakdown Products: Impact of ProcessingIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesSulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recyclingGlycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosisQuantitative image analysis of immunohistochemical stains using a CMYK color model.Transthiocarbamoylation of proteins by thiolated isothiocyanates.Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cellsSulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.Cancer stem cells: a novel paradigm for cancer prevention and treatment.Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions.Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2.Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice.Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity.Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy.Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate.Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cellsProposed criteria for assessing the efficacy of cancer reduction by plant foods enriched in carotenoids, glucosinolates, polyphenols and selenocompounds.SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide.Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells.Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane.Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway.Chemoprotection by sulforaphane: keep one eye beyond Keap1.Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.Sensitization of estrogen receptor-positive breast cancer cell lines to 4-hydroxytamoxifen by isothiocyanates present in cruciferous plants.Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.A review of the phytochemistry and pharmacological activities of raphani semen.Prevention of Carcinogen-Induced Oral Cancer by SulforaphaneActivation of ERK signaling and induction of colon cancer cell death by piperlongumine.Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanatesActivating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer.Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells.Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells.Cruciferous vegetable consumption and the risk of pancreatic cancer: a meta-analysis.
P2860
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P2860
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The dietary isothiocyanate sul ...... combined immunodeficient mice.
@en
type
label
The dietary isothiocyanate sul ...... combined immunodeficient mice.
@en
prefLabel
The dietary isothiocyanate sul ...... combined immunodeficient mice.
@en
P2093
P1476
The dietary isothiocyanate sul ...... combined immunodeficient mice.
@en
P2093
Aaron D Schimmer
David W Hedley
James W Jacobberger
Marcella Gronda
Nhu-An Pham
Pinjiang Cao
P304
P577
2004-10-01T00:00:00Z