Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis.
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The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tetheringLens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular responseTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityA tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivoStructural basis for high-affinity binding of LEDGF PWWP to mononucleosomesSpecificity of antinuclear autoantibodies recognizing the dense fine speckled nuclear pattern: Preferential targeting of DFS70/LEDGFp75 over its interacting partner MeCP2Identification of tumor-associated antigens as diagnostic and predictive biomarkers in cancer.Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigensExpression of the stress response oncoprotein LEDGF/p75 in human cancer: a study of 21 tumor types.Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoterLysophosphatidic acid enhances vascular endothelial growth factor-C expression in human prostate cancer PC-3 cells.A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases.Autoantibodies to tumor-associated antigens as biomarkers in cancer immunodiagnosis.Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene.LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer.LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathwayDiscovering Pair-wise Synergies in Microarray DataTumor-associated antigen arrays for the serological diagnosis of cancer.Mini-array of multiple tumor-associated antigens (TAAs) in the immunodiagnosis of breast cancer.Integrase, LEDGF/p75 and HIV replication.Using immunoproteomics to identify tumor-associated antigens (TAAs) as biomarkers in cancer immunodiagnosis.Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75.Detection of autoantibodies to DSF70/LEDGFp75 in Mexican Hispanics using multiple complementary assay platformsAlternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.Gonadotropin-regulated lymphangiogenesis in ovarian cancer is mediated by LEDGF-induced expression of VEGF-C.Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer.Serum autoantibodies as biomarkers for early cancer detection.Autoantibodies against oncogenic ERG protein in prostate cancer: potential use in diagnosis and prognosis in a panel with C-MYC, AMACR and HERV-K Gag.Autoantibodies to tumor-associated antigens as diagnostic biomarkers in hepatocellular carcinoma and other solid tumors.In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.The clinical significance of the dense fine speckled immunofluorescence pattern on HEp-2 cells for the diagnosis of systemic autoimmune diseasesCurrent concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies.Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding.PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes.Application of anti-DFS70 antibody and specific autoantibody test algorithms to patients with the dense fine speckled pattern on HEp-2 cells.The Clinical Relevance of Anti-DFS70 Autoantibodies.Analysis of DFS70 pattern and impact on ANA screening using a novel HEp-2 ELITE/DFS70 knockout substrate.LEDGF (p75) promotes DNA-end resection and homologous recombination.
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P2860
Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Antinuclear autoantibodies in ...... and cleaved during apoptosis.
@en
type
label
Antinuclear autoantibodies in ...... and cleaved during apoptosis.
@en
prefLabel
Antinuclear autoantibodies in ...... and cleaved during apoptosis.
@en
P2093
P356
P1433
P1476
Antinuclear autoantibodies in ...... and cleaved during apoptosis.
@en
P2093
Brian Yamada
Carlos A Casiano
Israel Gutierrez
Jianying Zhang
Mary Jo Heeb
Max L Elliot
Shaun M Sheets
Tracy Daniels
P356
10.1002/PROS.20112
P577
2005-01-01T00:00:00Z