Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV.
about
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injuryResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesPhosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsRole of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseasesA loss of FUS/TLS function leads to impaired cellular proliferationPhosphodiesterase type 4 inhibitor rolipram improves survival of spiral ganglion neurons in vitroA large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions.Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair.Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism.Treatment with the phosphodiesterase type-4 inhibitor rolipram fails to inhibit blood--brain barrier disruption in multiple sclerosis.Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potentialClinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.Epigenome-wide DNA methylation analysis in siblings and monozygotic twins discordant for sporadic Parkinson's disease revealed different epigenetic patterns in peripheral blood mononuclear cells.Can Cyclic Nucleotide Phosphodiesterase Inhibitors Be Drugs for Parkinson's Disease?Postulated vasoactive neuropeptide immunopathology affecting the blood-brain/blood-spinal barrier in certain neuropsychiatric fatigue-related conditions: A role for phosphodiesterase inhibitors in treatment?The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson's disease.Novel N-indolylmethyl substituted olanzapine derivatives: their design, synthesis and evaluation as PDE4B inhibitors.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress.
P2860
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P2860
Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Attenuation of MPTP neurotoxic ...... bitor of phosphodiesterase IV.
@en
type
label
Attenuation of MPTP neurotoxic ...... bitor of phosphodiesterase IV.
@en
prefLabel
Attenuation of MPTP neurotoxic ...... bitor of phosphodiesterase IV.
@en
P2093
P2860
P1476
Attenuation of MPTP neurotoxic ...... bitor of phosphodiesterase IV.
@en
P2093
Beverly J Lorenzo
Lichuan Yang
M Flint Beal
Noel Y Calingasan
P2860
P304
P356
10.1016/J.EXPNEUROL.2007.02.010
P407
P577
2007-02-27T00:00:00Z