Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
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Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkThyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activationThe antibodies against the computationally designed mimic of the glycoprotein hormone receptor transmembrane domain provide insights into receptor activation and suppress the constitutively activated receptor mutants.Antibody protection reveals extended epitopes on the human TSH receptor.Extended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain.Relationship between thyrotropin receptor hinge region proteolytic posttranslational modification and receptor physiological functionDefining structural and functional dimensions of the extracellular thyrotropin receptor region.The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine DiseasesThe thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activationThe thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.Evidence for cooperative signal triggering at the extracellular loops of the TSH receptorEvaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.Novel insights on thyroid-stimulating hormone receptor signal transduction.A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domainThe superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.Minireview: Insights Into the Structural and Molecular Consequences of the TSH-β Mutation C105Vfs114X.Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutationResearch resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses.Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.
P2860
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P2860
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Identification of a novel epit ...... molecular signaling interface.
@en
type
label
Identification of a novel epit ...... molecular signaling interface.
@en
prefLabel
Identification of a novel epit ...... molecular signaling interface.
@en
P2093
P2860
P356
P1476
Identification of a novel epit ...... molecular signaling interface.
@en
P2093
Gerd Krause
Gunnar Kleinau
Holger Jäschke
Jens Lättig
Ralf Paschke
Susanne Neumann
P2860
P304
51590-51600
P356
10.1074/JBC.M404748200
P407
P577
2004-09-02T00:00:00Z