about
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseStructure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor proteinBACE1 expression and activity: relevance in Alzheimer's diseaseΒ-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant.N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.The Alzheimer's disease beta-secretase enzyme, BACE1.Amyloid precursor protein and BACE function as oligomers.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondBACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer's Disease.Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease.Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.A specific inhibitor of cholesterol biosynthesis, BM15.766, reduces the expression of beta-secretase and the production of amyloid-beta in vitro.Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice.Cerebrospinal fluid BACE1 activity and brain amyloid load in Alzheimer's disease.Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Human BACE forms dimers and colocalizes with APP.
@en
type
label
Human BACE forms dimers and colocalizes with APP.
@en
prefLabel
Human BACE forms dimers and colocalizes with APP.
@en
P2093
P2860
P356
P1476
Human BACE forms dimers and colocalizes with APP.
@en
P2093
Andrea Schlicksupp
Ariane Schmechel
Markus Strauss
Rüdiger Pipkorn
Thomas A Bayer
P2860
P304
39710-39717
P356
10.1074/JBC.M402785200
P407
P577
2004-07-09T00:00:00Z