Identification of phosphate groups important to self-splicing of the Tetrahymena rRNA intron as determined by phosphorothioate substitution.
about
Defining the chemical groups essential for Tetrahymena group I intron function by nucleotide analog interference mappingBackbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozymeModular engineering of a Group I intron ribozyme.Magnesium ions mediate contacts between phosphoryl oxygens at positions 2122 and 2176 of the 23S rRNA and ribosomal protein L1.Selection of novel forms of a functional domain within the Tetrahymena ribozyme.Identification of phosphate oxygens that are important for self-cleavage activity of the HDV ribozyme by phosphorothioate substitution interference analysis.A phosphorothioate at the 3' splice-site inhibits the second splicing step in a group I intron.Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.Substrate-assisted catalysis in the cleavage of DNA by the EcoRI and EcoRV restriction enzymesIdentification of specific Rp-phosphate oxygens in the tRNA anticodon loop required for ribosomal P-site bindingBase pairing between the 3' exon and an internal guide sequence increases 3' splice site specificity in the Tetrahymena self-splicing rRNA intron.RNA structure and NMR spectroscopy.In vitro selection for altered divalent metal specificity in the RNase P RNA.Multiple metal-binding cores are required for metalloregulation by M-box riboswitch RNAsSingle substitutions of phosphorothioates in the HDV ribozyme G73 define regions necessary for optimal self-cleaving activity.Lead cleavage sites in the core structure of group I intron-RNA.Phosphorothioate substitution identifies phosphate groups important for pre-mRNA splicingIdentification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA.Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction.Phosphorothioate-containing RNAs show mRNA activity in the prokaryotic translation systems in vitro.The rate and specificity of a group I ribozyme are inversely affected by choice of monovalent salt.Extensive phosphorothioate substitution yields highly active and nuclease-resistant hairpin ribozymes.The environment of two metal ions surrounding the splice site of a group I intron.An RNA conformational change between the two chemical steps of group II self-splicing.The chemical basis of adenosine conservation throughout the Tetrahymena ribozyme.Artificial modules for enhancing rate constants of a Group I intron ribozyme without a P4-P6 core element.Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23.
P2860
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P2860
Identification of phosphate groups important to self-splicing of the Tetrahymena rRNA intron as determined by phosphorothioate substitution.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Identification of phosphate gr ...... phosphorothioate substitution.
@en
type
label
Identification of phosphate gr ...... phosphorothioate substitution.
@en
prefLabel
Identification of phosphate gr ...... phosphorothioate substitution.
@en
P2860
P356
P1476
Identification of phosphate gr ...... phosphorothioate substitution.
@en
P2093
R B Waring
P2860
P304
10281-10293
P356
10.1093/NAR/17.24.10281
P577
1989-12-01T00:00:00Z