Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.
about
IRS1-independent defects define major nodes of insulin resistanceSphingolipids in High Fat Diet and Obesity-Related DiseasesInsulin receptor signaling in normal and insulin-resistant statesChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsDefect of insulin signal in peripheral tissues: Important role of ceramideOmega-3 Fatty Acids and Skeletal Muscle HealthPharmacological inhibition of glucosylceramide synthase enhances insulin sensitivityThe effects of obesity on skeletal muscle regenerationThe PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cellsPalmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondriaParadoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscleRole of ceramide in diabetes mellitus: evidence and mechanisms.Multiple abnormalities of myocardial insulin signaling in a porcine model of diet-induced obesity.Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.In vitro palmitate treatment of myotubes from postmenopausal women leads to ceramide accumulation, inflammation and affected insulin signaling.Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.Tissue-specific insulin signaling in the regulation of metabolism and aging.Effects of endurance exercise and high-fat diet on insulin resistance and ceramide contents of skeletal muscle in sprague-dawley ratsRole of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet.Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.Ceramides and glucosylceramides are independent antagonists of insulin signalingShort-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stressProtein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells.Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubesEnhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A.New evidence for the role of ceramide in the development of hepatic insulin resistance.Ceramide-rich platforms in transmembrane signaling.Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscleMyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass.Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cellsRed Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory StudyAccelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model.Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in miceInsulin resistance: metabolic mechanisms and consequences in the heart.Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.
P2860
Q24647774-F5B73BD7-928C-4583-96B7-59A693438270Q26773230-BE2430B6-5424-4D6E-8C45-3C89F738776EQ26823171-FBCDA1D9-5FBC-4132-897F-EF0573A1BF1CQ27316876-EC38F96B-5CC1-41FE-B466-CDBC7D9DBE62Q27690875-CC7F239F-E25D-4BD1-9A99-1A81325EE142Q28084892-12AEEC88-1939-489C-8871-58899A87E2EFQ28287290-EFBEAD7F-48B9-4ED8-AA8A-2F16E0219963Q28393087-14FE7C15-1846-46BA-ACB0-F9EC36439089Q28569006-EB21B1F7-85DB-4F89-800B-BBB87F71E181Q28573343-64AAA3EF-29CB-4E9C-B5FC-52CE42E9D26DQ28743514-3BEB9D34-8CE9-40B3-9D79-158F16624151Q30351934-B007E1BC-68A9-4A33-B59F-3BBFC612879BQ33655989-FD41CF60-636D-411F-B1DF-2CA4F1F34E1EQ33688611-6DC2F14D-4E5A-42EC-BCB6-E9833EE1FE51Q33829692-49CCBB58-6CA8-458E-905D-C88F333E3407Q33855536-AF02EF0D-FD38-40B9-A0C8-46F30AC085FFQ33918445-6DBB73C9-2E5C-4F90-9E75-356F658AA78BQ33976122-303A2560-9CFB-479F-A80D-4D3729D994CAQ34076176-82782095-BFFD-41C5-BD76-4E04DE1D2BB0Q34101886-C0DFBE64-1A82-4D7C-85F0-AC97B046CE27Q34128783-9D3DA91B-D5FF-4896-80E4-7F54D6174BEAQ34132356-E4A5173C-788F-4617-89F5-18DAD8163378Q34384118-F5F52BA2-CAED-421D-A1B6-005C2B29B4AAQ34414178-8EBD848C-387C-4CD9-82A4-0BA1F223BEF1Q34426000-076B37FA-5153-4AC3-8B8C-C0570085EB6EQ34483701-7F07249F-5A27-43B2-B30C-DA7F7260332FQ34544900-C34A2B21-46BF-4F03-8FF6-4A8E9980A039Q35078615-4A26FD0F-F449-4981-9E21-9894C3E06303Q35121879-7CB48F97-DB48-47C8-9DBF-EA1C9D7B8DA1Q35551917-CE47ACC6-1D88-4F19-AA62-391AED89316FQ35633883-36D6B675-47E4-41A3-8F3B-2C966FCD2D7BQ35665651-8887E9D4-DA23-4028-842F-7F1247F1D323Q35813366-84140265-D4AD-497D-B2D1-8781D08AE48AQ35868797-3CC7C5D0-9B78-484D-B0F8-03929CD3DB6BQ35875222-6D46B319-F1EE-4A06-A4EA-E65A3ADFF109Q35924961-FD517E02-3D64-443D-978B-82F26D301512Q36179961-19E8F50E-CB44-4738-96A7-0BEBC045E704Q36621447-E4A11875-984A-4391-BFF6-CF0D27124B39Q36821424-8D3E85EA-27BA-4979-8E54-8B816B8DEB7DQ36856230-A9B56C06-E0C4-4958-B396-27961826FB85
P2860
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Intracellular ceramide synthes ...... rat L6 skeletal muscle cells.
@en
type
label
Intracellular ceramide synthes ...... rat L6 skeletal muscle cells.
@en
prefLabel
Intracellular ceramide synthes ...... rat L6 skeletal muscle cells.
@en
P2093
P2860
P356
P1433
P1476
Intracellular ceramide synthes ...... rat L6 skeletal muscle cells.
@en
P2093
Alexander Gray
Darren J Powell
Eric Hajduch
Harinder S Hundal
Sophie Turban
P2860
P304
P356
10.1042/BJ20040139
P407
P577
2004-09-01T00:00:00Z