Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. - Wikidata - wikimedia - TriplyDB

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

http://www.wikidata.org/entity/Q40548177

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Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2 Central mediators involved in the febrile response: effects of antipyretic drugs Psychogenic fever: how psychological stress affects body temperature in the clinical population Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2 Cellular and molecular bases of the initiation of fever PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness.The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.Prostaglandin E2 synthases in neurologic homeostasis and disease Food deprivation alters thermoregulatory responses to lipopolysaccharide by enhancing cryogenic inflammatory signaling via prostaglandin D2 Novel human mPGES-1 inhibitors identified through structure-based virtual screening.Hypothalamic mechanisms in cachexia.Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione.Mechanisms of fever production and lysis: lessons from experimental LPS fever.Fever and the thermal regulation of immunity: the immune system feels the heat.Minor changes in gene expression in the mouse preoptic hypothalamic region by inflammation-induced prostaglandin E2.Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.Neural controls of prostaglandin 2 pyrogenic, tachycardic, and anorexic actions are anatomically distributed.Inflammation-induced lethargy is mediated by suppression of orexin neuron activity Inflammatory pathways in children with insufficient or disordered sleep.The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme.Cyclooxygenase Isoform Exchange Blocks Brain-Mediated Inflammatory Symptoms Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.Microsomal prostaglandin E synthase-1, ephrins, and ephrin kinases as suspected therapeutic targets in arthritis: exposed by "criminal profiling".Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice.Immune-to-brain signaling and central prostaglandin E2 synthesis in fasted rats with altered lipopolysaccharide-induced fever Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction.Immune-to-brain signaling: how important are the blood-brain barrier-independent pathways?Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells.Prostanoids in health and disease.Inflammation-induced anorexia and fever are elicited by distinct prostaglandin dependent mechanisms, whereas conditioned taste aversion is prostaglandin independent.Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain.New insights into eicosanoid biosynthetic pathways: implications for arthritis.Microsomal prostaglandin e synthase-1 in rheumatic diseases.Neural circuitry engaged by prostaglandins during the sickness syndrome.

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P2860

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

http://www.wikidata.org/entity/Q40548177

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2003 nî lūn-bûn

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Microsomal prostaglandin E syn ...... during immune-induced pyresis.

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Microsomal prostaglandin E syn ...... during immune-induced pyresis.

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Microsomal prostaglandin E syn ...... during immune-induced pyresis.

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Nature Neuroscience

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Microsomal prostaglandin E syn ...... during immune-induced pyresis.

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P2093

David Engblom

http://www.w3.org/2001/XMLSchema#string

Laurent P Audoly

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Linda Engström

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Marie Westman

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Per-Johan Jakobsson

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Sipra Saha

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P2860

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

Fever: links with an ancient receptor.

Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.

Prostaglandins as inflammatory messengers across the blood-brain barrier.

Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever.

Mechanisms of CNS response to systemic immune challenge: the febrile response.

Inflammatory response: pathway across the blood-brain barrier.

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1137-1138

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10.1038/NN1137

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11

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6

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Anders Blomqvist

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2003-10-19T00:00:00Z

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1016552997

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14566340

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