Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1.
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In vitro selection, characterization, and application of deoxyribozymes that cleave RNAHistone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and interferon regulatory factor-1Portal branch ligation induces a hepatic arterial buffer response, microvascular remodeling, normoxygenation, and cell proliferation in portal blood-deprived liver tissue.Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours.Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis.Growth hormone potentiates 17β-estradiol-dependent breast cancer cell proliferation independently of IGF-I receptor signaling.MicroRNA-gene association as a prognostic biomarker in cancer exposes disease mechanismsHydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects.Deoxyribozymes: new therapeutics to treat central nervous system disordersFine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer riskCatalytic deoxyribozyme-modified nanoparticles for RNAi-independent gene regulationNitric Oxide Regulates Gene Expression in Cancers by Controlling Histone Posttranslational Modifications.In-vitro and in-vivo assays for angiogenesis-modulating drug discovery and development.Preclinical anticancer activity of DNA-based cleavage molecules.A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem CellsBrothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model.Gene therapy for osteosarcoma: steps towards clinical studies.Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancerCancer, chitosan nanoparticles and catalytic nucleic acids.Review: doxorubicin delivery systems based on chitosan for cancer therapy.The distribution, clearance, and safety of an anti-MMP-9 DNAzyme in normal and MMTV-PyMT transgenic mice.ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC.NF-kappaΒ-inducing kinase regulates stem cell phenotype in breast cancer.Dz13: c-Jun downregulation and tumour cell death.Deoxyribozymes and bioinformatics: complementary tools to investigate axon regeneration.Therapeutic potential of siRNA and DNAzymes in cancer.DNAzyme-based biosensors and nanodevices.DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes.EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids.EBV-LMP1-targeted DNAzyme restrains nasopharyngeal carcinoma growth in a mouse C666-1 xenograft model.Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient miceTransactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells.Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis.CD44 induced enhancement of phosphatase activity and calcium influx: Modifications of EGR-1 expression and cell proliferation.New approaches for cancer treatment: antitumor drugs based on gene-targeted nucleic acids.Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells.Turning the 10-23 DNAzyme on and off with light.Inhibition of beta-lactamase-mediated oxacillin resistance in Staphylococcus aureus by a deoxyribozyme.CCCTC-binding factor inhibits breast cancer cell proliferation and metastasis via inactivation of the nuclear factor-kappaB pathway.
P2860
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P2860
Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumour growth by DNAzymes targeting the zinc finger transcription factor EGR-1.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Inhibition of human breast car ...... er transcription factor EGR-1.
@en
type
label
Inhibition of human breast car ...... er transcription factor EGR-1.
@en
prefLabel
Inhibition of human breast car ...... er transcription factor EGR-1.
@en
P2093
P2860
P356
P1476
Inhibition of human breast car ...... er transcription factor EGR-1.
@en
P2093
Ainslie Mitchell
Crispin R Dass
Levon M Khachigian
Lun-Quan Sun
P2860
P304
P356
10.1093/NAR/GKH626
P577
2004-06-04T00:00:00Z