Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons.
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beta-Amyloid degradation and Alzheimer's diseaseRegulation of distinct pools of amyloid β-protein by multiple cellular proteasesProtective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse modelsNeprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Curcumin inhibits the AKT/NF-κB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line.A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injuryLipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.The involvement of lipid rafts in Alzheimer's disease.Distinct subcellular patterns of neprilysin protein and activity in the brains of Alzheimer's disease patients, transgenic mice and cultured human neuronal cells.Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's DiseaseMetabolism of amyloid β peptide and pathogenesis of Alzheimer's disease.Localization of mature neprilysin in lipid rafts.Potent amyloidogenicity and pathogenicity of Aβ43.Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, anHIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytesChoroid plexus implants rescue Alzheimer's disease-like pathologies by modulating amyloid-β degradation.The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism.
P2860
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P2860
Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Effects of neprilysin chimeric ...... clearance in primary neurons.
@en
type
label
Effects of neprilysin chimeric ...... clearance in primary neurons.
@en
prefLabel
Effects of neprilysin chimeric ...... clearance in primary neurons.
@en
P2093
P2860
P356
P1476
Effects of neprilysin chimeric ...... clearance in primary neurons.
@en
P2093
Keiro Shirotani
Nobuhisa Iwata
Takaomi C Saido
P2860
P304
30259-30264
P356
10.1074/JBC.M401891200
P407
P577
2004-04-20T00:00:00Z