A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. - Wikidata - wikimedia - TriplyDB

A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.

A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.

http://www.wikidata.org/entity/Q40584630

about

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation Critical role for Daxx in regulating Mdm2 Daxx is reciprocally regulated by Mdm2 and Hausp DAXX is a new AIRE-interacting protein The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62 Negative regulation of p53 functions by Daxx and the involvement of MDM2 ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression ATRX directs binding of PRC2 to Xist RNA and Polycomb targets Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3 Negative modulation of androgen receptor transcriptional activity by Daxx The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2 The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis Signal transducer and activator of transcription 3 regulation by novel binding partners Linking epithelial-to-mesenchymal-transition and epigenetic modifications Histone regulation in the CNS: basic principles of epigenetic plasticity Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Distinct factors control histone variant H3.3 localization at specific genomic regions Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells Comparative analysis of the ATRX promoter and 5' regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular function Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons Histone variants: emerging players in cancer biology.Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.Loss of Atrx sensitizes cells to DNA damaging agents through p53-mediated death pathways Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.Fruit flies and intellectual disability.p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase.DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase.Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease Microtubule stability, Golgi organization, and transport flux require dystonin-a2-MAP1B interaction.ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation Compromised genomic integrity impedes muscle growth after Atrx inactivation.The replication defect of ICP0-null mutant herpes simplex virus 1 can be largely complemented by the combined activities of human cytomegalovirus proteins IE1 and pp71

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P2860

A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.

http://www.wikidata.org/entity/Q40584630

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

2004年论文

@zh

2004年论文

@zh-cn

name

A novel transcription regulato ...... nd the ATR-X syndrome protein.

@en

type

label

A novel transcription regulato ...... nd the ATR-X syndrome protein.

@en

prefLabel

A novel transcription regulato ...... nd the ATR-X syndrome protein.

@en

P1433

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P1476

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P356

P1433

Journal of Biological Chemistry

P1476

A novel transcription regulato ...... nd the ATR-X syndrome protein.

@en

P2093

David J Picketts

http://www.w3.org/2001/XMLSchema#string

Hongtu Liu

http://www.w3.org/2001/XMLSchema#string

Jun Tang

http://www.w3.org/2001/XMLSchema#string

Orr G Barak

http://www.w3.org/2001/XMLSchema#string

Rachael Stratt

http://www.w3.org/2001/XMLSchema#string

Ramin Shiekhattar

http://www.w3.org/2001/XMLSchema#string

Shaobo Wu

http://www.w3.org/2001/XMLSchema#string

Xiaolu Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Sequestration and inhibition of Daxx-mediated transcriptional repression by PML

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes

Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm

The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex

Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

P304

20369-20377

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P31

scholarly article

P356

10.1074/JBC.M401321200

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P407

P433

19

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P478

279

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P577

2004-02-27T00:00:00Z

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P698

14990586

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