Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells.
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FADD phosphorylation is critical for cell cycle regulation in breast cancer cellsInduction of apoptosis in human leukemia cells by grape seed extract occurs via activation of c-Jun NH2-terminal kinaseJNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development.Targeting c-Jun and JunB proteins as potential anticancer cell therapyCXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activationActivation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stressEffect of JNK inhibitor SP600125 on hair cell regeneration in zebrafish (Danio rerio) larvae.JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells.Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation.Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.L1 Cell Adhesion Molecule Promotes Migration and Invasion via JNK Activation in Extrahepatic Cholangiocarcinoma Cells with Activating KRAS Mutation.Activation of the Jun N-terminal kinase pathway by friend spleen focus-forming virus and its role in the growth and survival of friend virus-induced erythroleukemia cells.Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasmActivation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells.Functional estrogen receptors in the mitochondria of breast cancer cellsA whole-genome RNA interference screen for human cell factors affecting myxoma virus replicationc-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis.JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB.Exposure to excess estradiol or leptin during pregnancy increases mammary cancer risk and prevents parity-induced protective genomic changes in ratsc-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cellsc-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancerGrb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle ProgressionSelective killing of p53-deficient cancer cells by SP600125.Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer.Autotetraploid cell line induced by SP600125 from crucian carp and its developmental potentialityThromboxane A2 Receptor Inhibition Suppresses Multiple Myeloma Cell Proliferation by Inducing p38/c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase (MAPK)-mediated G2/M Progression Delay and Cell Apoptosis.Effects of CDK4/6 Inhibition in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Cells with Acquired Resistance to Paclitaxel.Understanding signaling cascades in melanomaHyaluronan and hyaluronidase in genitourinary tumors.Hyalurondiase: both a tumor promoter and suppressor.JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis.Linking JNK Activity to the DNA Damage Response.Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.The role of mitogen- and stress-activated protein kinase pathways in melanoma.SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways.Role of p21 in SP600125-induced cell cycle arrest, endoreduplication, and apoptosis.
P2860
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P2860
Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Inhibition of JNK reduces G2/M ...... ptosis in breast cancer cells.
@en
type
label
Inhibition of JNK reduces G2/M ...... ptosis in breast cancer cells.
@en
prefLabel
Inhibition of JNK reduces G2/M ...... ptosis in breast cancer cells.
@en
P2093
P2860
P356
P1433
P1476
Inhibition of JNK reduces G2/M ...... ptosis in breast cancer cells.
@en
P2093
Amy M Mingo-Sion
Carla L Van Den Berg
Douglas M Wolf
Erich Koller
Peter M Marietta
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207147
P407
P577
2004-01-01T00:00:00Z
P5875
P6179
1009352974