about
Stable expression of FRET biosensors: a new light in cancer researchDistinct predictive performance of Rac1 and Cdc42 in cell migrationVisualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo.An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cellsSH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.Quantification of local morphodynamics and local GTPase activity by edge evolution tracking.Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold proteinQuantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactionsIntercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin.Processive phosphorylation of ERK MAP kinase in mammalian cellsDevelopment of an optimized backbone of FRET biosensors for kinases and GTPases.Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active MoleculesMechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells.Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transferSynergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging.Variegated RHOA mutations in adult T-cell leukemia/lymphoma.Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Förster Resonance Energy Transfer (FRET): Implications for signaling and pharmacology.Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: basis of biosensor construction, live imaging, and image processing.mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation.A quantitative model of ERK MAP kinase phosphorylation in crowded mediaFRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells.The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors.Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF.Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer.Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK.Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression.Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells.Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs.Propagating Wave of ERK Activation Orients Collective Cell Migration.Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling.Inverse tissue mechanics of cell monolayer expansion.Monitoring spatio-temporal regulation of Ras and Rho GTPase with GFP-based FRET probes.Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters.Improvement of the bioluminescence reporter system for real-time monitoring of circadian rhythms in the cyanobacterium Synechocystis sp. strain PCC 6803.Development of a FRET biosensor with high specificity for Akt.Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Kazuhiro Aoki
@ast
Kazuhiro Aoki
@en
Kazuhiro Aoki
@es
Kazuhiro Aoki
@nl
Kazuhiro Aoki
@sl
type
label
Kazuhiro Aoki
@ast
Kazuhiro Aoki
@en
Kazuhiro Aoki
@es
Kazuhiro Aoki
@nl
Kazuhiro Aoki
@sl
prefLabel
Kazuhiro Aoki
@ast
Kazuhiro Aoki
@en
Kazuhiro Aoki
@es
Kazuhiro Aoki
@nl
Kazuhiro Aoki
@sl
P1053
B-5777-2013
P106
P1153
8866176400
P21
P31
P3829
P3835
kazuhiro-aoki
P496
0000-0001-7263-1555
P569
2000-01-01T00:00:00Z