pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities.
about
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleDNA-damage-responsive acetylation of pRb regulates binding to E2F-1p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisProapoptotic function of the retinoblastoma tumor suppressor proteinTopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survivalRB1: a prototype tumor suppressor and an enigmaMolecular mechanisms underlying RB protein functionStructure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressorTranscriptional control of stem cell fate by E2Fs and pocket proteinsRB regulates pancreas development by stabilizing Pdx1Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain.The retinoblastoma tumor-suppressor gene, the exception that proves the ruleE2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression.Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1BInteraction of the retinoblastoma protein with Orc1 and its recruitment to human origins of DNA replication.RORĪ± binds to E2F1 to inhibit cell proliferation and regulate mammary gland branching morphogenesisDNA damage signals through differentially modified E2F1 molecules to induce apoptosis.Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.Generation of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model.Regulation of T cell differentiation and alloimmunity by the cyclin-dependent kinase inhibitor p18ink4cRole of Drosophila retinoblastoma protein instability element in cell growth and proliferationThe rb pathway and cancer therapeuticsUnique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functionsAttempted cell cycle induction in post-mitotic neurons occurs in early and late apoptotic programs through Rb, E2F1, and caspase 3JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein.Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressor.Life and death decisions by the E2F transcription factors.pRB-E2F1 complexes are resistant to adenovirus E1A-mediated disruption.Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage.pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location.RB goes mitochondrialCataloging and organizing p73 interactions in cell cycle arrest and apoptosisE2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant rasRB1, development, and cancer.Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental rolesBalancing the decision of cell proliferation and cell fate.RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1.Diversity within the pRb pathway: is there a code of conduct?
P2860
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P2860
pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities.
description
2003 nĆ® lÅ«n-bĆ»n
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2003幓ć®č«ę
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2003幓č«ę
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2003幓č«ę
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2003幓č«ę
@zh-hk
2003幓č«ę
@zh-mo
2003幓č«ę
@zh-tw
2003幓č®ŗę
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2003幓č®ŗę
@zh
2003幓č®ŗę
@zh-cn
name
pRB contains an E2F1-specific ...... ely from other E2F activities.
@en
type
label
pRB contains an E2F1-specific ...... ely from other E2F activities.
@en
prefLabel
pRB contains an E2F1-specific ...... ely from other E2F activities.
@en
P1433
P1476
pRB contains an E2F1-specific ...... ely from other E2F activities.
@en
P2093
Frederick A Dick
Nick Dyson
P304
P356
10.1016/S1097-2765(03)00344-7
P577
2003-09-01T00:00:00Z