about
Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damageCLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegenerationA synthetic biology approach identifies the mammalian UPR RNA ligase RtcBThe human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAsThe human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.Analysis of 2'-phosphotransferase (Tpt1p) from Saccharomyces cerevisiae: evidence for a conserved two-step reaction mechanism.Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transferPlant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic originsStructure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reactionCrystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thalianaStructure of RNA 3′-phosphate cyclase bound to substrate RNAA 2'-phosphotransferase implicated in tRNA splicing is essential in Saccharomyces cerevisiaeHydrolase regulates NAD+ metabolites and modulates cellular redox.Dual functions of yeast tRNA ligase in the unfolded protein response: unconventional cytoplasmic splicing of HAC1 pre-mRNA is not sufficient to release translational attenuation.Characterization of the Saccharomyces cerevisiae cyclic nucleotide phosphodiesterase involved in the metabolism of ADP-ribose 1",2"-cyclic phosphate.Transient ADP-ribosylation of a 2'-phosphate implicated in its removal from ligated tRNA during splicing in yeastNew insights into the RNA-based mechanism of action of the anticancer drug 5'-fluorouracil in eukaryotic cellsA functional homolog of a yeast tRNA splicing enzyme is conserved in higher eukaryotes and in Escherichia coliAn intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligationtRNA biology charges to the frontStructural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPaseHealing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.Branchiostoma floridae has separate healing and sealing enzymes for 5'-phosphate RNA ligation.Junction phosphate is derived from the precursor in the tRNA spliced by the archaeon Haloferax volcanii cell extract.Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturationReconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro.RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivoSPL1-1, a Saccharomyces cerevisiae mutation affecting tRNA splicing.CLP1 links tRNA metabolism to progressive motor-neuron loss.A host-specific function is required for ligation of a wide variety of ribozyme-processed RNAs.Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1.Structure-activity relationships in human RNA 3'-phosphate cyclase.Diversity and roles of (t)RNA ligases.Handling tRNA introns, archaeal way and eukaryotic way.CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.The two RNA ligases of the Trypanosoma brucei RNA editing complex: cloning the essential band IV gene and identifying the band V gene.Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.The stereochemical course of the first step of pre-mRNA splicing.Archaeal RNA ligase is a homodimeric protein that catalyzes intramolecular ligation of single-stranded RNA and DNA.Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo.
P2860
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P2860
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Conserved mechanism of tRNA splicing in eukaryotes.
@en
type
label
Conserved mechanism of tRNA splicing in eukaryotes.
@en
prefLabel
Conserved mechanism of tRNA splicing in eukaryotes.
@en
P2093
P2860
P356
P1476
Conserved mechanism of tRNA splicing in eukaryotes.
@en
P2093
E M Phizicky
M A Gorovsky
M Zillmann
P2860
P304
P356
10.1128/MCB.11.11.5410
P407
P577
1991-11-01T00:00:00Z