Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis.
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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic functionRegulation of Bim in Health and DiseaseContracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?Apoptosis and the homeostatic control of immune responses.Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of BimB-cell homeostasis: digital survival or analog growth?Modulation and function of caspase pathways in B lymphocytes.Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer.The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia.Autophagy delays apoptotic death in breast cancer cells following DNA damage.Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL.The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells.Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover.Growth-factor-dependent phosphorylation of Bim in mitosis.MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.Quantitative phosphoproteome analysis of cisplatin-induced apoptosis in Jurkat T cells.Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway.c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
P2860
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P2860
Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Phosphorylation of the pro-apo ...... ith protection from apoptosis.
@en
type
label
Phosphorylation of the pro-apo ...... ith protection from apoptosis.
@en
prefLabel
Phosphorylation of the pro-apo ...... ith protection from apoptosis.
@en
P2093
P1433
P1476
Phosphorylation of the pro-apo ...... ith protection from apoptosis.
@en
P2093
Brigitte T Huber
Priska D von Haller
Robert J Seward
P304
P356
10.1016/S0161-5890(03)00047-6
P577
2003-06-01T00:00:00Z