Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases.
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Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B SynthaseSolution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseStructural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking DomainsCyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product BiosynthesisTowards prediction of metabolic products of polyketide synthases: an in silico analysisX-ray Scattering Studies of Protein Structural Dynamics.Combinatorial biosynthesis of polyketides--a perspective.A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection.The origins of specificity in polyketide synthase protein interactions.Probing the compatibility of type II ketosynthase-carrier protein partners.Supported membrane composition analysis by secondary ion mass spectrometry with high lateral resolution.Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase.Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.Engineering polyketide synthases and nonribosomal peptide synthetases.Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthaseThe enzymology of combinatorial biosynthesis.Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthaseEngineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide SynthasesRobust platform for de novo production of heterologous polyketides and nonribosomal peptides in Escherichia coli.Mechanism and specificity of an acyltransferase domain from a modular polyketide synthaseStructural analysis of protein-protein interactions in type I polyketide synthasesIn vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase.Structural insights into nonribosomal peptide enzymatic assembly linesEngineering the acyltransferase substrate specificity of assembly line polyketide synthases.The structural role of the carrier protein--active controller or passive carrier.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Structure and mechanism of assembly line polyketide synthases.Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase.Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis.Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase.Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domainsN-activated β-lactams as versatile reagents for acyl carrier protein labelingRole of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases.Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase
P2860
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P2860
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Quantitative analysis of the r ...... n hybrid polyketide synthases.
@en
type
label
Quantitative analysis of the r ...... n hybrid polyketide synthases.
@en
prefLabel
Quantitative analysis of the r ...... n hybrid polyketide synthases.
@en
P2093
P356
P1433
P1476
Quantitative analysis of the r ...... n hybrid polyketide synthases.
@en
P2093
Chaitan Khosla
David E Cane
Nicholas Wu
P304
P356
10.1021/BI012086U
P407
P577
2002-04-01T00:00:00Z