Caffeine mimics adenine and 2'-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.
about
The enigmatic effects of caffeine in cell cycle and cancerATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases.Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines.
P2860
Caffeine mimics adenine and 2'-deoxyadenosine, both of which inhibit the guanine-nucleotide exchange activity of RCC1 and the kinase activity of ATR.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Caffeine mimics adenine and 2' ...... nd the kinase activity of ATR.
@en
type
label
Caffeine mimics adenine and 2' ...... nd the kinase activity of ATR.
@en
prefLabel
Caffeine mimics adenine and 2' ...... nd the kinase activity of ATR.
@en
P2093
P2860
P1433
P1476
Caffeine mimics adenine and 2' ...... nd the kinase activity of ATR.
@en
P2093
Hideo Nishitani
Hitoshi Nishijima
Noriko Saito
Takeharu Nishimoto
P2860
P304
P356
10.1046/J.1365-2443.2003.00644.X
P577
2003-05-01T00:00:00Z