Local anaesthetics transiently block currents through single acetylcholine-receptor channels.
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Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cellsOpen channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine.Epibatidine activates muscle acetylcholine receptors with unique site selectivity.Effects of serotonergic agents on neuronal nicotinic acetylcholine receptorsEnd-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseIon channel activity of influenza A virus M2 protein: characterization of the amantadine blockModulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cellsStructural basis of open channel block in a prokaryotic pentameric ligand-gated ion channelAdvances and hold-ups in the study of structure, function and regulation of Cys-loop ligand-gated ion channels and receptorsModes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscleOpen probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancyCorrelation of agonist structure with acetylcholine receptor kinetics: studies on the frog end-plate and on chick embryo muscleA unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanismsCurare binding and the curare-induced subconductance state of the acetylcholine receptor channelArgiopine blocks glutamate-activated single-channel currents on crayfish muscle by two mechanismsVoltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic AcidThe natural history of consciousness, and the question of whether plants are conscious, in relation to the Hameroff-Penrose quantum-physical 'Orch OR' theory of universal consciousness.Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.How fast does the GluR1Qflip channel open?Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane.Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.Intrinsic versus extrinsic voltage sensitivity of blocker interaction with an ion channel poreThe noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.Cocaine: mechanism of inhibition of a muscle acetylcholine receptor studied by a laser-pulse photolysis technique.Synporins--synthetic proteins that emulate the pore structure of biological ionic channels.Sequencing and the single channelStructurally diverse amphiphiles exhibit biphasic modulation of GABAA receptors: similarities and differences with neurosteroid actions.Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.Point mutations in alpha bENaC regulate channel gating, ion selectivity, and sensitivity to amiloride.Reconstitution of highly purified saxitoxin-sensitive Na+-channels into planar lipid bilayers.Effects of intracellular K+ and Rb+ on gating of embryonic rat telencephalon Ca(2+)-activated K+ channels.Channel blocking properties of a series of nicotinic cholinergic agonists.Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel.Analysis of cyclic and acyclic nicotinic cholinergic agonists using radioligand binding, single channel recording, and nuclear magnetic resonance spectroscopy.Open channel block and beyond.Pore conformations and gating mechanism of a Cys-loop receptor.Small iminium ions block gramicidin channels in lipid bilayers.Sensitivity to voltage-independent inhibition determined by pore-lining region of the acetylcholine receptor.Electrostatic interactions regulate desensitization of the nicotinic acetylcholine receptor.
P2860
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P2860
Local anaesthetics transiently block currents through single acetylcholine-receptor channels.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
Local anaesthetics transiently ...... etylcholine-receptor channels.
@en
type
label
Local anaesthetics transiently ...... etylcholine-receptor channels.
@en
prefLabel
Local anaesthetics transiently ...... etylcholine-receptor channels.
@en
P2860
P1476
Local anaesthetics transiently ...... etylcholine-receptor channels.
@en
P2093
P2860
P304
P356
10.1113/JPHYSIOL.1978.SP012267
P407
P577
1978-04-01T00:00:00Z