The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway.
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Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347The c-Rel transcription factor and B-cell proliferation: a deal with the devilIdentification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter.Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profileRelB/NF-κB2 regulates corticotropin-releasing hormone in the human placenta.Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation.Deletion analysis and alternative splicing define a transactivation inhibitory domain in human oncoprotein RELHistone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.Oncogenic activation of NF-kappaB.Cell transformation by v-Rel reveals distinct roles of AP-1 family members in Rel/NF-kappaB oncogenesis.NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway.µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis.The c-Rel Transcription Factor in Development and Disease.Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.Histone acetyltransferase-deficient p300 mutants in diffuse large B cell lymphoma have altered transcriptional regulatory activities and are required for optimal cell growth.t(11;14)(q23;q32) involving IGH and DDX6 in nodal marginal zone lymphoma.LMP1 and Dynamic Progressive Telomere Dysfunction: A Major Culprit in EBV-Associated Hodgkin's Lymphoma.A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity.Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma.Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosisDeletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells.Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity.Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma.An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation.
P2860
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P2860
The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-kappaB signal transduction pathway.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The human B-cell lymphoma cell ...... B signal transduction pathway.
@en
type
label
The human B-cell lymphoma cell ...... B signal transduction pathway.
@en
prefLabel
The human B-cell lymphoma cell ...... B signal transduction pathway.
@en
P2093
P356
P1433
P1476
The human B-cell lymphoma cell ...... B signal transduction pathway.
@en
P2093
Andreas Rosenwald
Demetrios Kalaitzidis
Louis M Staudt
R Eric Davis
Thomas D Gilmore
P2888
P304
P356
10.1038/SJ.ONC.1206033
P407
P577
2002-12-01T00:00:00Z
P5875
P6179
1035860975