Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. - Wikidata - wikimedia - TriplyDB

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

http://www.wikidata.org/entity/Q40685661

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Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2 Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets 9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2 Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs Possible novel receptor for PGD2 on human bronchial epithelial cells Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: Δ(12)-prostaglandin J3 PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2 The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Prostanoid receptor antagonists: development strategies and therapeutic applications Peroxisome proliferator-activated receptor γ is essential for secretion of ANP induced by prostaglandin D2 in the beating rat atrium.Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids Opposing roles of prostaglandin D2 receptors in ulcerative colitis Prostaglandin D2 DP1 receptor is beneficial in ischemic stroke and in acute exicitotoxicity in young and old mice Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes.Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.Inverse agonist and pharmacochaperone properties of MK-0524 on the prostanoid DP1 receptor Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity.The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling.Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.Putative role of prostaglandin receptor in intracerebral hemorrhage.Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation.Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions.An eicosanoid-centric view of atherothrombotic risk factors The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses Using guinea pigs in studies relevant to asthma and COPD.DP(2) receptor antagonists in development.Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma.A novel DP2 receptor antagonist (AM-461): a patent evaluation of WO2011085033.Therapeutic implications of disorders of cell death signalling: membranes, micro-environment, and eicosanoid and docosanoid metabolism Eosinophil recruitment and activation: the role of lipid mediators.Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.Discovery of anti-inflammatory role of prostaglandin D2.15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.Physiological and Pathological Roles of 15-Deoxy-Δ12,14-Prostaglandin J2 in the Central Nervous System and Neurological Diseases.Association of CRTH2 gene polymorphisms with the required dose of antihistamines in patients with chronic urticaria.Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.

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P2860

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

http://www.wikidata.org/entity/Q40685661

description

2002 nî lūn-bûn

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2002年の論文

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Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

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Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

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Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

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British Journal of Pharmacology

P1476

Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

@en

P2093

Anne Chateauneuf

http://www.w3.org/2001/XMLSchema#string

Donald W Nicholson

http://www.w3.org/2001/XMLSchema#string

Elizabeth Cauchon

http://www.w3.org/2001/XMLSchema#string

Francois G Gervais

http://www.w3.org/2001/XMLSchema#string

Gary P O'Neill

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Kathleen M Metters

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Nicole Sawyer

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Rani P G Cruz

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P2860

Selective expression of a novel surface molecule by human Th2 cells in vivo

Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

Molecular cloning and characterization of the human prostanoid DP receptor

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor

Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist

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1163-1172

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scholarly article

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10.1038/SJ.BJP.0704973

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8

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137

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2002-12-01T00:00:00Z

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7010371

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12466225

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1573602

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