Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor.
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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonistsDopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid raftsChemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous ScarringDiversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular PerspectivesHIV: cell binding and entryStructural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine familyOptogenetic control of chemokine receptor signal and T-cell migration.Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1alpha N-terminus.Thermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes.Chemokine receptor oligomerization and allostery.Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells.CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells.Consequences of ChemR23 heteromerization with the chemokine receptors CXCR4 and CCR7.Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine.Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation.An analysis of oligomerization interfaces in transmembrane proteins.Multiplex detection of homo- and heterodimerization of g protein-coupled receptors by proximity biotinylationHighly potent chimeric inhibitors targeting two steps of HIV cell entryTargeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis.Cell, isoform, and environment factors shape gradients and modulate chemotaxisRoles of G-protein-coupled receptor dimerization.Fluorescence lifetime endoscopy using TCSPC for the measurement of FRET in live cells.Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4.Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway.A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry.Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor.Regulation of CXCR4 signaling.CXCR4-CCR5: a couple modulating T cell functionsThe US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4.Imaging chemokine receptor dimerization with firefly luciferase complementation.Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells.Chemokine signaling in cancer: one hump or two?The role of tyrosine sulfation in the dimerization of the CXCR4:SDF-1 complex.Modulation of chemokine receptor activity through dimerization and crosstalk
P2860
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P2860
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor.
@en
type
label
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor.
@en
prefLabel
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor.
@en
P356
P1476
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor.
@en
P2093
Gregory J Babcock
P304
P356
10.1074/JBC.M210140200
P407
P577
2002-11-13T00:00:00Z