about
Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous NephropathyDomain structure and conformation of histidine-proline-rich glycoproteinDistinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminalsAnti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathwaysAlport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic α3(IV) collagen autoepitopes in vivo.Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung.Molecular characterization of the target antigens of anti-glomerular basement membrane antibody disease.Pathogenesis of Goodpasture syndrome: a molecular perspective.Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruptionA human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.Murine membranous nephropathy: immunization with α3(IV) collagen fragment induces subepithelial immune complexes and FcγR-independent nephrotic syndrome.The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.Quaternary epitopes of α345(IV) collagen initiate Alport post-transplant anti-GBM nephritisThe extracellular matrix of hydra is a porous sheet and contains type IV collagenDistinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.Cellular origins of type IV collagen networks in developing glomeruli.Stem cell therapy for Alport syndrome: the hope beyond the hype.A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.Neonatal Fc receptor promotes immune complex-mediated glomerular disease.Glomerular basement membrane heparan sulfate in health and disease: A regulator of local complement activation.Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains.The goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain.The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain.Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy.Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease.Mouse models of membranous nephropathy: the road less travelled by.Interstitial mononuclear infiltrates in murine α3(IV)-NC1-induced nephropathy: harbingers of renal failure?Effects of histidine-proline-rich glycoprotein on plasminogen activation in solution and on surfaces.Correction: Increased Expression of SVCT2 in a New Mouse Model Raises Ascorbic Acid in Tissues and Protects against Paraquat-Induced Oxidative Damage in Lung.Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone.A case of subepidermal blistering disease with autoantibodies to multiple laminin subunits who developed later autoantibodies to alpha-5 chain of type IV collagen associated with membranous glomerulonephropathy.Kidney development and gene expression in the HIF2alpha knockout mouse.Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis.Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.Loss of alpha3/alpha4(IV) collagen from the glomerular basement membrane induces a strain-dependent isoform switch to alpha5alpha6(IV) collagen associated with longer renal survival in Col4a3-/- Alport mice.Hydrophobic amino acid residues are critical for the immunodominant epitope of the Goodpasture autoantigen. A molecular basis for the cryptic nature of the epitopeThe NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranesType IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domainsHistidine-proline-rich glycoprotein as a plasma pH sensor. Modulation of its interaction with glycosaminoglycans by ph and metals
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
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name
Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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type
label
Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Borza, D.B.
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Dorin Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
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Dorin-Bogdan Borza
@sl
P106
P31
P496
0000-0003-4568-279X