Conformational and topographical considerations in the design of biologically active peptides.
about
A paradigm shift: Cancer therapy with peptide-based B-cell epitopes and peptide immunotherapeutics targeting multiple solid tumor types: Emerging concepts and validation of combination immunotherapyLigand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsStructure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation.Peptide interactions with G-protein coupled receptors.Organic chemistry and biology: chemical biology through the eyes of collaboration.Peptide vaccines and peptidomimetics of EGFR (HER-1) ligand binding domain inhibit cancer cell growth in vitro and in vivoA computer screening approach to immunoglobulin superfamily structures and interactions: discovery of small non-peptidic CD4 inhibitors as novel immunotherapeuticsPeptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapyNew theoretical methodology for elucidating the solution structure of peptides from NMR data. II. Free energy of dominant microstates of Leu-enkephalin and population-weighted average nuclear Overhauser effects intensities.Structure based antibody-like peptidomimetics.Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles.Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.Diversity-oriented synthesis of medicinally important 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives and higher analogs.Mimicking Peptides… In Silico.A light-activated beta-turn scaffold within a somatostatin analog: NMR structure and biological activity.Molecular organization of receptors. Efficacy, agonists, and antagonists.Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.Crystal structures of peptides and modified peptides.Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographicallCalpha methylation in molecular recognition. Application to substance P and the two neurokinin-1 receptor binding sites.Synthesis, biology, NMR and conformation studies of the topographically constrained delta-opioid selective peptide analogs of [beta-iPrPhe(3)]deltorphin I.Aziridine-Mediated Ligation at Phenylalanine and Tryptophan Sites.On the bioactive conformation of a small peptide and its set of thermodynamically accessible conformations.Design of peptides, proteins, and peptidomimetics in chi space.Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo.
P2860
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P2860
Conformational and topographical considerations in the design of biologically active peptides.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Conformational and topographic ...... biologically active peptides.
@en
type
label
Conformational and topographic ...... biologically active peptides.
@en
prefLabel
Conformational and topographic ...... biologically active peptides.
@en
P356
P1433
P1476
Conformational and topographic ...... biologically active peptides.
@en
P2093
P304
P356
10.1002/BIP.360330709
P577
1993-07-01T00:00:00Z