Crystal structure of wild-type human thrombin in the Na+-free state.
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Structure of Human Prostasin, a Target for the Regulation of HypertensionStructure of granzyme C reveals an unusual mechanism of protease autoinhibitionMolecular basis of thrombomodulin activation of slow thrombinMutant N143P Reveals How Na+ Activates ThrombinGpIbα Interacts Exclusively with Exosite II of ThrombinEnsemble refinement shows conformational flexibility in crystal structures of human complement factor DThe dynamic structure of thrombin in solutionProton bridging in the interactions of thrombin with hirudin and its mimics.Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.How Na+ activates thrombin--a review of the functional and structural data.NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.Thrombin inhibition by serpins disrupts exosite IIEvidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies.Fast photochemical oxidation of proteins for epitope mappingA guided mode resonance aptasensor for thrombin detection.Role of Na+ and K+ in enzyme function.Thrombin.Exosites in the substrate specificity of blood coagulation reactions.Slow thrombin is zymogen-likeNMR reveals a dynamic allosteric pathway in thrombin.Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).3-Nitrotyrosine as a spectroscopic probe for investigating protein protein interactions.A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation.Amide H/2H exchange reveals a mechanism of thrombin activation.High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.Uncovering Large-Scale Conformational Change in Molecular Dynamics without Prior Knowledge.Visualizing correlated motion with HDBSCAN clustering.Interplay between conformational selection and zymogen activation.
P2860
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P2860
Crystal structure of wild-type human thrombin in the Na+-free state.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
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2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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2005年學術文章
@zh-hant
name
Crystal structure of wild-type human thrombin in the Na+-free state.
@en
type
label
Crystal structure of wild-type human thrombin in the Na+-free state.
@en
prefLabel
Crystal structure of wild-type human thrombin in the Na+-free state.
@en
P2093
P2860
P356
P1433
P1476
Crystal structure of wild-type human thrombin in the Na+-free state
@en
P2093
Daniel J D Johnson
James A Huntington
Ty E Adams
P2860
P356
10.1042/BJ20051217
P407
P50
P577
2005-11-01T00:00:00Z