Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis. - Wikidata - wikimedia - TriplyDB

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

http://www.wikidata.org/entity/Q40731596

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Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability The RNA polymerase I transcription machinery RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins Nucleolus: the fascinating nuclear body Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth Nuclear export modulates the cytoplasmic Sir2 homologue Hst2.DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.Role of histone deacetylase Rpd3 in regulating rRNA gene transcription and nucleolar structure in yeast.Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes.Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.Nucleolar dominance and ribosomal RNA gene silencing Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.Regulation of ribosomal RNA production by RNA polymerase I: does elongation come first?rRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switch RNA-polymerase-I-directed rDNA transcription, life and works.Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway.Modulation of RNA polymerase assembly dynamics in transcriptional regulation.Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I.Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.Coordination of Ribosomal Protein and Ribosomal RNA Gene Expression in Response to TOR Signaling.Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress.RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae Regulation of ribosomal gene expression in cancer.TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis.Identification of EhTIF-IA: The putative E. histolytica orthologue of the human ribosomal RNA transcription initiation factor-IA.Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients.Rrn3 becomes inactivated in the process of ribosomal DNA transcription.Characterization of the interactions of mammalian RNA polymerase I associated proteins PAF53 and PAF49.The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.Regulation of the association of the PAF53/PAF49 heterodimer with RNA polymerase I Photocross-linking of the RNA polymerase I preinitiation and immediate postinitiation complexes: implications for promoter recruitment.PAF53 is essential in mammalian cells: CRISPR/Cas9 fails to eliminate PAF53 expression.

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P2860

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

http://www.wikidata.org/entity/Q40731596

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

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type

label

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

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prefLabel

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

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Journal of Biological Chemistry

P1476

Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis.

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P2093

Alice H Cavanaugh

http://www.w3.org/2001/XMLSchema#string

Iwona Hirschler-Laszkiewicz

http://www.w3.org/2001/XMLSchema#string

Lawrence I Rothblum

http://www.w3.org/2001/XMLSchema#string

Miroslav Dundr

http://www.w3.org/2001/XMLSchema#string

Qiyue Hu

http://www.w3.org/2001/XMLSchema#string

Tom Misteli

http://www.w3.org/2001/XMLSchema#string

Tom Smink

http://www.w3.org/2001/XMLSchema#string

P2860

TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p

Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters

Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

Repression of RNA polymerase I transcription by the tumor suppressor p53

Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF

RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human

Gene RPA43 in Saccharomyces cerevisiae encodes an essential subunit of RNA polymerase I.

Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription.

The recruitment of RNA polymerase I on rDNA is mediated by the interaction of the A43 subunit with Rrn3

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27423-27432

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10.1074/JBC.M201232200

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30

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277

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2002-05-15T00:00:00Z

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12015311

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P921

phosphorylation