RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and
about
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol estersAn essential role for RasGRP1 in mast cell function and IgE-mediated allergic responseUnusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesMultiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functionsCalDAG-GEFI integrates signaling for platelet aggregation and thrombus formationRasGRPs are targets of the anti-cancer agent ingenol-3-angelateDiacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signalingDevelopment of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation.Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cellsRegulation and Function of the RasGRP Family of Ras Activators in Blood CellsAberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis.The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogensMammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.Sigma-class glutathione transferases.Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics.RasGRP Ras guanine nucleotide exchange factors in cancer.GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines.Rap1 activation plays a regulatory role in pancreatic amylase secretion.Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras.Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells.LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival.
P2860
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P2860
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
RasGRP4, a new mast cell-restr ...... ast cell leukemia patients and
@en
type
label
RasGRP4, a new mast cell-restr ...... ast cell leukemia patients and
@en
prefLabel
RasGRP4, a new mast cell-restr ...... ast cell leukemia patients and
@en
P2093
P2860
P921
P356
P1476
RasGRP4, a new mast cell-restr ...... ast cell leukemia patients and
@en
P2093
Guang W Wong
M S Madhusudhan
Richard L Stevens
Steven A Krilis
P2860
P304
25756-25774
P356
10.1074/JBC.M202575200
P407
P50
P577
2002-04-15T00:00:00Z