Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. - Wikidata - wikimedia - TriplyDB

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.

http://www.wikidata.org/entity/Q40738359

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Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?Fluconazole and Echinocandin Resistance of Candida glabrata Correlates Better with Antifungal Drug Exposure Rather than with MSH2 Mutator Genotype in a French Cohort of Patients Harboring Low Rates of Resistance.Azole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species.Optimizing antifungal strategies to improve patient survival.Azole Resistance in Candida glabrata.Echinocandin Resistance in Candida Species: a Review of Recent Developments.Genetic Drivers of Multidrug Resistance in Candida glabrata.The antifungal pipeline: a reality check.Rapid Detection of FKS-Associated Echinocandin Resistance in Candida glabrata Antifungal Resistance: An Emerging Reality and A Global Challenge.Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment.Harnessing Whole Genome Sequencing in Medical Mycology.The Role of In Vitro Susceptibility Testing in the Management of Candida and Aspergillus.Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli.Chitin Oligosaccharide (COS) Reduces Antibiotics Dose and Prevents Antibiotics-Caused Side Effects in Adolescent Idiopathic Scoliosis (AIS) Patients with Spinal Fusion Surgery.Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes Echinocandin Resistance in Candida glabrata Isolates.Echinocandin Resistance in Candida Species Isolates from Liver Transplant Recipients.Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species.Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates.Antifungal resistance: current trends and future strategies to combat.Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii.FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans.Population Structure of Candida parapsilosis: No Genetic Difference Between French and Uruguayan Isolates Using Microsatellite Length Polymorphism.The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination.Combination of 247 genome-wide association studies reveals high cancer risk as a result of evolutionary adaptation.Update from a twelve-year nationwide fungaemia surveillance: increasing intrinsic and acquired resistance causes concern.Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds.Candida glabrata Biofilms: How Far Have We Come?The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance.Invasive Fungal Infections in Patients with Hematological Malignancies: Emergence of Resistant Pathogens and New Antifungal Therapies.Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata.Development of echinocandin resistance in Candida tropicalis following short-term exposure to caspofungin for empiric therapy.Mutant prevention concentration and mutant selection window of micafungin and anidulafungin in clinical Candida glabrata isolates.De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance.Sign of selection on mutation rate modifiers depends on population size.Absence of azole or echinocandin resistance in Candida glabrata isolates in India despite background prevalence of strains with defects in DNA mismatch repair pathway.

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P2860

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.

http://www.wikidata.org/entity/Q40738359

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2016 nî lūn-bûn

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Prevalent mutator genotype ide ...... romotes multi-drug resistance.

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type

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Prevalent mutator genotype ide ...... romotes multi-drug resistance.

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prefLabel

Prevalent mutator genotype ide ...... romotes multi-drug resistance.

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Nature Communications

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Prevalent mutator genotype ide ...... romotes multi-drug resistance.

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Barbara D Alexander

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Cristina Jimenez-Ortigosa

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David S Perlin

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Dimitrios Farmakiotis

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Dimitrios P Kontoyiannis

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Jack D Sobel

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Saad J Taj-Aldeen

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Winder B Perez

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Yanan Zhao

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P2860

Antimicrobial-induced DNA damage and genomic instability in microbial pathogens

Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study

Epidemiology of invasive candidiasis: a persistent public health problem

A conserved MutS homolog connector domain interface interacts with MutL homologs.

Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice.

Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy.

Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata

Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance.

The changing epidemiology of healthcare-associated candidemia over three decades.

Drug-resistant Candida glabrata infection in cancer patients.

P2888

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10.1038/NCOMMS11128

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7

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Dominique Sanglard

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2016-03-29T00:00:00Z

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299501545

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27020939

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Candida glabrata

multiple drug resistance

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5603725

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