PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.
about
Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathwaysNegative feedback regulation of the ERK1/2 MAPK pathwayPAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activationPAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signalingERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migrationAdhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylationPak1 as a novel therapeutic target for antihypertrophic treatment in the heartRac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexesMitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion.MEK1 activation by PAK: a novel mechanism.Glia maturation factor-γ mediates neutrophil chemotaxisThe Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.Cadherins and Pak1 control contact inhibition of proliferation by Pak1-betaPIX-GIT complex-dependent regulation of cell-matrix signaling.Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancersTgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling.The WNKs: atypical protein kinases with pleiotropic actions.Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion.Oncogenic Ras in tumour progression and metastasis.Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants.PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survivalA p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression.Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cellsProlactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.Integrated analysis of breast cancer cell lines reveals unique signaling pathways.PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness.Pak protein kinases and their role in cancer.Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis.Rho GTPases as regulators of morphological neuroplasticity.Targeting the Ras-ERK pathway in pancreatic adenocarcinoma.PAK signaling in cancer.Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases.P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.Characterization of Ser338 phosphorylation for Raf-1 activationPeroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2.Epidermal growth factor and/or growth hormone induce differential, side-specific signal transduction protein phosphorylation in enterocytes.
P2860
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P2860
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
PAK1 primes MEK1 for phosphory ...... activation of the ERK pathway.
@en
type
label
PAK1 primes MEK1 for phosphory ...... activation of the ERK pathway.
@en
prefLabel
PAK1 primes MEK1 for phosphory ...... activation of the ERK pathway.
@en
P2860
P356
P1433
P1476
PAK1 primes MEK1 for phosphory ...... activation of the ERK pathway
@en
P2093
Lucy C Coles
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205302
P407
P50
P577
2002-03-01T00:00:00Z
P5875
P6179
1039479260