Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.
about
From animal models to human disease: a genetic approach for personalized medicine in ALSUbiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells.Ubiquilin/Dsk2 promotes inclusion body formation and vacuole (lysosome)-mediated disposal of mutated huntingtinMotor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.Old versus New Mechanisms in the Pathogenesis of ALS.Motoneuron Disease: Basic Science.Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage.Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia.Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly
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P2860
Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.
description
2015 nî lūn-bûn
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2015年学术文章
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name
Viral expression of ALS-linked ...... d behavioral deficits in mice.
@en
type
label
Viral expression of ALS-linked ...... d behavioral deficits in mice.
@en
prefLabel
Viral expression of ALS-linked ...... d behavioral deficits in mice.
@en
P2093
P2860
P1476
Viral expression of ALS-linked ...... d behavioral deficits in mice.
@en
P2093
Amanda Sacino
Awilda M Rosario
Carolina Ceballos-Diaz
Corey Moran
Hyo-Jin Park
Natalia Ravelo
Nicolas Lara
Paramita Chakrabarty
Pedro E Cruz
Todd E Golde
P2860
P2888
P356
10.1186/S13024-015-0026-7
P577
2015-07-08T00:00:00Z
P5875
P6179
1043868973