Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.
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High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathwayPhysiology and pathology of endothelin-1 in renal mesangium.Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species.Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis.hERG gating microdomains defined by S6 mutagenesis and molecular modeling.A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.Electrophysiological characterization of three non-synonymous single nucleotide polymorphisms (R87Q, A251T, and P307S) found in hKv1.5.Role of the S6 C-terminus in KCNQ1 channel gating.Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.A synthetic S6 segment derived from KvAP channel self-assembles, permeabilizes lipid vesicles, and exhibits ion channel activity in bilayer lipid membrane.Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase.Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-beta produced by tubular epithelial cells in response to high glucose.Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase C.Redox dependence of glomerular epithelial cell hypertrophy in response to glucose.High glucose condition upregulated Txnip expression level in rat mesangial cells through ROS/MEK/MAPK pathway.
P2860
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P2860
Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.
description
2002 nî lūn-bûn
@nan
2002年の論文
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2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
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2002年學術文章
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name
Mutations throughout the S6 re ...... bility of the activation gate.
@en
type
label
Mutations throughout the S6 re ...... bility of the activation gate.
@en
prefLabel
Mutations throughout the S6 re ...... bility of the activation gate.
@en
P2093
P2860
P1476
Mutations throughout the S6 re ...... ability of the activation gate
@en
P2093
Michael M Tamkun
Sarita W Yeola
Thomas C Rich
P2860
P304
P356
10.1152/AJPCELL.00232.2001
P577
2002-01-01T00:00:00Z