Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
about
Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertensionPlexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironmentMeasuring right ventricular function in the normal and hypertensive mouse hearts using admittance-derived pressure-volume loopsActivation of peroxisome proliferator-activated receptor γ ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertensionThe Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis.Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferationThe role of collagen synthesis in ventricular and vascular adaptation to hypoxic pulmonary hypertensionThe role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertensionRegulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.Matricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease.Thrombospondins: A Role in Cardiovascular Disease.Thrombospondin-1, endothelium and systemic vascular tone.HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstrictionHypoxia does neither stimulate pulmonary artery endothelial cell proliferation in mice and rats with pulmonary hypertension and vascular remodeling nor in human pulmonary artery endothelial cells.Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment.TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.What mediates the effects of thrombospondin-1 in pulmonary hypertension? New evidence for a dual-pronged role of CD47.'Hypoxio-spondin': thrombospondin and its emerging role in pulmonary hypertension.
P2860
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P2860
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
description
2010 nî lūn-bûn
@nan
2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
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2010年學術文章
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name
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
@en
type
label
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
@en
prefLabel
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
@en
P2093
P2860
P356
P1476
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
@en
P2093
Charles A Hales
Cristhiaan D Ochoa
Deborah A Quinn
Essam Al-Ansari
P2860
P2888
P356
10.1186/1749-8090-5-32
P577
2010-05-04T00:00:00Z
P5875
P6179
1038855556