Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel.
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The c-Rel transcription factor and B-cell proliferation: a deal with the devilTargeting NF-kappaB in hematologic malignanciesc-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cellsRNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo.Deletion analysis and alternative splicing define a transactivation inhibitory domain in human oncoprotein RELHistone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-κB and upregulation of IL-1Ra in melanoma modelMutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity.Mouse mammary tumor virus c-rel transgenic mice develop mammary tumors.The c-Rel Transcription Factor in Development and Disease.IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphomaIKKβ-I-κBɛ-c-Rel/p50: a new axis of NF-κB activation in lung epithelial cells.Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cellsRepression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins.CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein v-Rel.Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family.CRISPR/Cas9-mediated knockout of c-REL in HeLa cells results in profound defects of the cell cycle.Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival.Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype.Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8.A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling.Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosisThe p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth.Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells.Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity.An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation.The Human Cytomegalovirus Strain DB Activates Oncogenic Pathways in Mammary Epithelial Cells.The Role of the Transcription Factor Nuclear Factor-kappa B in Thyroid Autoimmunity and CancerThe Human Cytomegalovirus, from Oncomodulation to Oncogenesis
P2860
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P2860
Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
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2001年學術文章
@zh-hant
name
Malignant transformation of pr ...... an transcription factor c-Rel.
@en
type
label
Malignant transformation of pr ...... an transcription factor c-Rel.
@en
prefLabel
Malignant transformation of pr ...... an transcription factor c-Rel.
@en
P2093
P2860
P356
P1433
P1476
Malignant transformation of pr ...... an transcription factor c-Rel.
@en
P2093
Gapuzan ME
Gilmore TD
Jean-Jacques J
P2860
P2888
P304
P356
10.1038/SJ.ONC.1204898
P407
P577
2001-10-01T00:00:00Z
P5875
P6179
1044611773