Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte - Wikidata - wikimedia - TriplyDB

Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte

Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte

http://www.wikidata.org/entity/Q40786230

about

Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes Studying GPCR/cAMP pharmacology from the perspective of cellular structure CaV1.2 signaling complexes in the heart Compartmentalization of β-adrenergic signals in cardiomyocytes Signaling epicenters: the role of caveolae and caveolins in volatile anesthetic induced cardiac protection.Caveolin contributes to the modulation of basal and β-adrenoceptor stimulated function of the adult rat ventricular myocyte by simvastatin: a novel pleiotropic effect Sarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotection Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation.Culture and adenoviral infection of sinoatrial node myocytes from adult mice A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation.Caveolins: targeting pro-survival signaling in the heart and brain.Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy.Spatial control of the βAR system in heart failure: the transverse tubule and beyond.Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling.Super-resolution scanning patch clamp reveals clustering of functional ion channels in adult ventricular myocyte.Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.Simvastatin Promotes Cardiac Myocyte Relaxation in Association with Phosphorylation of Troponin I.Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts.PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation.The effects of aging on the regulation of t-tubular ICa by caveolin in mouse ventricular myocytes.Cholesterol depletion does not alter the capacitance or Ca handling of the surface or t-tubule membranes in mouse ventricular myocytes.Loss of caveolin-3-dependent regulation of ICa in rat ventricular myocytes in heart failure.Caveolins as regulators of stress adaptation.Caveolin 3-dependent loss of t-tubular ICa during hypertrophy and heart failure in mice.Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.A novel approach to the Langendorff technique: preparation of isolated cardiomyocytes and myocardial samples from the same rat heart.PDE4 and mAKAPβ are nodal organizers of β2-ARs nuclear PKA signaling in cardiac myocytes.Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes.Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains

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P2860

Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte

http://www.wikidata.org/entity/Q40786230

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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2011年學術文章

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2011年學術文章

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Caveolae compartmentalise β2-a ...... the adult ventricular myocyte

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J.YJMCC.2011.06.014

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Journal of Molecular and Cellular Cardiology

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Caveolae compartmentalise β2-a ...... the adult ventricular myocyte

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Anna L Longster

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David A Macdougall

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Elizabeth A Stopford

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Hongjin Chu

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Jennifer A Collins

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John Colyer

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Sarah Calaghan

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P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels

Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

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388-400

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10.1016/J.YJMCC.2011.06.014

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2

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52

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Robert D. Harvey

Shailesh R. Agarwal

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2011-06-26T00:00:00Z

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51478556

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21740911

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3270222

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