Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. - Wikidata - wikimedia - TriplyDB

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

http://www.wikidata.org/entity/Q40791331

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Analyzing effects of naturally occurring missense mutations Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis In silico and in vitro investigations of the mutability of disease-causing missense mutation sites in spermine synthase Naturally occurring carboxypeptidase A6 mutations: effect on enzyme function and association with epilepsy.Proteome-derived peptide libraries to study the substrate specificity profiles of carboxypeptidases.Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.Carboxypeptidases in disease: insights from peptidomic studies.Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: a molecular dynamics approach.Carbamazepine Prevents Hippocampal Neurodegeneration in Mice Lacking the Neuroprotective Protein, Carboxypetidase E.Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.Hypothalamic proopiomelanocortin processing and the regulation of energy balance Predicting folding free energy changes upon single point mutations Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative.New roles of carboxypeptidase E in endocrine and neural function and cancer.Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function Neuropeptide-processing enzymes: applications for drug discovery.Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: a molecular dynamics approach The regulated secretory pathway and human disease: insights from gene variants and single nucleotide polymorphisms.Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake N-terminal truncated carboxypeptidase E expression is associated with poor prognosis of lung adenocarcinoma.Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids).[Screening of Highly Expressed CPEΔN Lung Cancer H1299 Cells].Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.Functional analysis of PCSK2 coding variants: A founder effect in the Old Order Amish population.Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population.Overexpression of CPE-ΔN predicts poor prognosis in colorectal cancer patients.Processing of Proinsulin to Insulin Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis.Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))

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P2860

Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

http://www.wikidata.org/entity/Q40791331

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2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

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2001年學術文章

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2001年學術文章

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Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

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type

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Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

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Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.

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Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity

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Chan G

http://www.w3.org/2001/XMLSchema#string

Chayen S

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Chen H

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Duong Q

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Fricker LD

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Gross DJ

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Jawahar S

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Meyer JM

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Moore KJ

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Parker A

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P2860

Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains

Crystal structure of avian carboxypeptidase D domain II: a prototype for the regulatory metallocarboxypeptidase subfamily

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4

Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity

Carboxypeptidase E

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120-131

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10.1002/HUMU.1161

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2

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18

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Benjamin Glaser

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2001-08-01T00:00:00Z

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11462236

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