Opposing effects of molecular volume and charge at the hyperekplexia site alpha 1(P250) govern glycine receptor activation and desensitization.
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The Intracellular Loop of the Glycine Receptor: It's not all about the SizeThe impact of human hyperekplexia mutations on glycine receptor structure and functionRecessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stabilityGlycine receptor mouse mutants: model systems for human hyperekplexiaThe role of intracellular linkers in gating and desensitization of human pentameric ligand-gated ion channelsChemical and genetic engineering of selective ion channel-ligand interactionsHydroxylated residues influence desensitization behaviour of recombinant alpha3 glycine receptor channels.Glycine Receptors Caught between Genome and Proteome - Functional Implications of RNA Editing and Splicing.The structural mechanism of the Cys-loop receptor desensitization.Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.The novel hyperekplexia allele GLRA1(S267N) affects the ethanol site of the glycine receptor.Mutations at the GABA receptor selectivity filter: a possible role for effective charges.Selective potentiation of alpha 1 glycine receptors by ginkgolic acid.Disturbances of Ligand Potency and Enhanced Degradation of the Human Glycine Receptor at Affected Positions G160 and T162 Originally Identified in Patients Suffering from Hyperekplexia.Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors.Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure.The GlyR Extracellular β8-β9 Loop - A Functional Determinant of Agonist Potency.Synergistic inhibition of glycinergic transmission in vitro and in vivo by flavonoids and strychnine.Overexpression and functional characterization of the extracellular domain of the human alpha1 glycine receptor.Functional characterization of compound heterozygosity for GlyRalpha1 mutations in the startle disease hyperekplexia.Conserved high affinity ligand binding and membrane association in the native and refolded extracellular domain of the human glycine receptor alpha1-subunit.Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.A missense mutation A384P associated with human hyperekplexia reveals a desensitization site of glycine receptors.Impaired Glycine Receptor Trafficking in Neurological Diseases
P2860
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P2860
Opposing effects of molecular volume and charge at the hyperekplexia site alpha 1(P250) govern glycine receptor activation and desensitization.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Opposing effects of molecular ...... ctivation and desensitization.
@en
type
label
Opposing effects of molecular ...... ctivation and desensitization.
@en
prefLabel
Opposing effects of molecular ...... ctivation and desensitization.
@en
P2093
P2860
P356
P1476
Opposing effects of molecular ...... ctivation and desensitization.
@en
P2093
Breitinger HG
Villmann C
P2860
P304
29657-29663
P356
10.1074/JBC.M100446200
P407
P577
2001-06-06T00:00:00Z