sameAs
L-alanine 406 replaced with L-threonineL-aspartic acid residue 351 replaced with glycineL-aspartic acid 351 replaced with L-histidineL-aspartic acid residue 351 replaced with L-tyrosineL-lysine residue 428 replaced with L-threonineL-proline residue 356 replaced with L-leucineL-proline residue 356 replaced with L-arginineL-arginine residue 361 replaced with L-cysteineL-arginine residue 361 replaced with L-histidineL-arginine residue 515 replaced with L-threonineSMAD4 ser-unknown phosphorylated
P279
p-2S-SMAD2/3:SMAD4p-2S-SMAD2/3:SMAD4 [nucleoplasm]SMAD4:p-SMAD2:p-SMAD2SMAD4 MH2 domain mutantsp-T;2S-SMAD2/3:SMAD4Ub-SMAD4Ub-SMAD4 [cytosol]Ub-SMAD4:USP9Xp-2S-SMAD1:p-2S-SMAD1:SMAD4p-2S-SMAD3:p-2S-SMAD3:SMAD4p-2S-SMAD1/5/8:SMAD4p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4USP9X (FAM) deubiquitinates SMAD4SMURF2 monoubiquitinates SMAD3PPM1A dephosphorylates nuclear SMAD2/3Phospho-R-Smad1/5/8 forms a complex with Co-Smad
P527
P688
Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoterSignal transduction of bone morphogenetic protein receptorsSmad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formationTransforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factorsGermline mutations in SMAD4 disrupt bone morphogenetic protein signalingHepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathwayStoichiometry of active smad-transcription factor complexes on DNAA colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potentialDual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexesSmad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionHeteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4Cellular response to hypoxia involves signaling via Smad proteinsBone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cellsReceptor-associated Mad homologues synergize as effectors of the TGF-beta responseHMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transitionHEB and E2A function as SMAD/FOXH1 cofactorsVascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endotheliumTranscriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivatorCrystal structure of a transcriptionally active Smad4 fragmentThe novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses.Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
P921
Q50369816-AEEFBCEF-D499-4462-8E6C-5FA84F963EFBQ50369817-9788DE3D-FA02-4CE3-8119-FC9555DC3300Q50369818-FAB3F8A1-3C70-4452-8557-5250E0E2E094Q50369819-0C1C5DA5-8EB0-4FD5-9BD8-F3D22074C044Q50369820-5D2151ED-9A9C-432F-9158-B819381A29EAQ50369821-AB6A8A52-9A79-4EFD-8BCC-54DCD9EA7FC9Q50369822-710A8AFB-9188-4FFB-99A0-5BDE76341EBAQ50369823-44DF833C-EE66-4D09-A27F-CBBB89F1CE19Q50369824-766C56B0-7D65-4402-8C0E-75CE2F072404Q50369825-176ACAF9-E1F0-4B4D-9CA9-F47F431610D2Q50371989-9112AA93-1F1E-42A5-BF34-C80828DED29E
P279
Q50255080-F89FB053-A2BC-4FEB-8B55-784FCDB5D3AEQ50255083-0C8EE930-667D-4E81-9F09-8ED1EAD4CA72Q50255125-B5498BB4-A1ED-430F-80AC-CB6BF042008EQ50256074-D99D4451-0FE3-4E7C-ADFE-0BF8059DEEEDQ50257923-00779BFA-88F8-4D18-BDBD-30C6A233DB1CQ50257946-0F2DB1BE-49AB-49D7-BCDD-8E114CD5FEBEQ50257947-C6B593BB-5FD1-49E8-8289-E36C664DA077Q50257948-C019634A-ED2D-4F3E-B3C4-2B4FDA1FC43CQ50258500-F3FE5BF6-3893-4813-A889-8A5F946DE098Q50258519-9FCF68EA-5367-45F4-A342-75BA6FE8CB79Q50272290-6639B9AD-A4FF-4EF5-9B2D-40A3ED27C1B7Q50272292-03D0A6C1-8451-4EF1-A2A5-854C4D7ACFDBQ50287870-8A987647-2E07-4BC1-ACAE-5EAF8FD2BA9AQ50288844-82F5B5F0-7301-4967-A761-C1929979A6B8Q50290131-11F61D88-651B-4A96-9081-3B68F2A8CA87Q50290136-C4C85C44-D479-4788-9413-A27FAB72CAE2Q50290141-B2C420D4-54C5-4EA5-BB2A-2F6E9A2115DCQ50298211-E3410A71-EDC9-4E29-8C36-0AA7C69525D5
P527
Q22254141-0CA84EEB-1AD5-4767-A985-FA3FAFBC178EQ24302298-B55D2592-A2F0-4EBD-9798-2862E96267B3Q24302554-FF84C812-0B30-4942-B1F7-6F746B6F3C0AQ24303642-7A8F9964-A734-4C3A-9A35-F720BE498371Q24304900-8EE5572C-95A1-4A4C-AD9C-23EC1FDCDFB1Q24307549-A4C22F24-A3AF-463D-AA80-F0B2B38FD9E8Q24310563-C213C5AB-DE0F-4B8E-818F-5A34687786B1Q24310649-AEF0DBAE-2CCC-4934-97CC-99F3EB6463F0Q24310852-77385B71-6BE8-4F97-96DD-A94A4F622254Q24311810-168F551C-0A43-4151-8585-6CF3D3FB0BEEQ24314569-2D9E2784-A6F8-4366-B92B-E15821104894Q24314661-F9F4641E-ED51-461B-9408-6E2072B833D9Q24314797-EA5C9349-6F39-481B-9D45-9BB29FCD73AFQ24315838-561A3C03-A510-4D88-B30C-BDB8B2FC7E3EQ24318330-A9FC22BD-F9C3-4D47-8E1D-E0B90A388905Q24318681-683577C5-04B3-4FF9-A233-51DA95ECCC8BQ24320356-2BF093B4-E5A1-437B-922F-5E22AEB9292AQ24322926-46421996-5B68-4142-8118-E668801DE054Q24324502-3A6AFD7C-6952-4639-BD5C-EE94BB9D3398Q27621046-F76E9A78-43E4-4E40-8D53-9FA6A3057118Q34538658-65650514-DD1B-4DE9-B2BD-37240B69A817Q41683351-4BF85388-E1ED-4B06-902D-477FAFAFA63DQ90465976-475968C4-4209-42B6-8724-079CB7D6619D
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين في الإنسان العاقل
@ar
name
MAD-Homolog 4
@de
Mothers against decapentaplegic homolog 4
@pl
SMAD family member 4
@en
SMAD family member 4
@nl
SMAD4
@cy
SMAD4
@es
SMAD4
@fa
SMAD4
@uk
Smad 4
@fr
type
label
MAD-Homolog 4
@de
Mothers against decapentaplegic homolog 4
@pl
SMAD family member 4
@en
SMAD family member 4
@nl
SMAD4
@cy
SMAD4
@es
SMAD4
@fa
SMAD4
@uk
Smad 4
@fr
altLabel
Co-SMAD
@de
MAD homolog 4
@en
MADH4
@pl
SMAD 4
@en
SMAD, mothers against DPP homolog 4
@en
SMAD4
@en
SMAD4
@pl
Smad4
@fr
deleted in pancreatic carcinoma locus 4
@en
deletion target in pancreatic carcinoma 4
@en
prefLabel
MAD-Homolog 4
@de
Mothers against decapentaplegic homolog 4
@pl
SMAD family member 4
@en
SMAD family member 4
@nl
SMAD4
@cy
SMAD4
@es
SMAD4
@fa
SMAD4
@uk
Smad 4
@fr
P361
P527
P638
P672
P680
P681
P682
P705
P352
P486
P6366
P637
P646
P672
P2888
P31
P352
P486
P6366
P637
P638
P646
P672
D12.644.360.024.334.750
D12.776.157.057.170.750
D12.776.260.713.750
D12.776.476.024.428.750
D12.776.624.776.760
D12.776.930.806.750
P680
P681
P682
P702
P703
P705
ENSP00000341551
ENSP00000381452
ENSP00000464772
ENSP00000464901
ENSP00000465874
ENSP00000465878
ENSP00000466118
ENSP00000466934
ENSP00000468611
ENSP00000478613