Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells
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Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic AgentsSmad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosisInterleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.Mechanisms of ganglioside inhibition of APC function.Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth.Elevated levels of select gangliosides in T cells from renal cell carcinoma patients is associated with T cell dysfunction.T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets.Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.T cell-NF-κB activation is required for tumor control in vivoReprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells.Resistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell lymphoma cell lines.Advances in immune-based therapies of renal cell carcinoma.Transforming growth factor β1 (TGF-β1) suppresses growth of B-cell lymphoma cells by p14(ARF)-dependent regulation of mutant p53.TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expressionSphingolipids: regulators of crosstalk between apoptosis and autophagyMemory T cells in human tumor and chronic inflammatory microenvironments: sleeping beauties re-awakened by a cytokine kiss.Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells.Signaling defects in anti-tumor T cellsIL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments.Is there a role for presurgical therapy for renal cell carcinoma?Basic research in kidney cancer.Targeted therapy in renal cancer.Cutting Edge: Engineering Active IKKβ in T Cells Drives Tumor Rejection.MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles.Ganglioside-exposed dendritic cells inhibit T-cell effector function by promoting regulatory cell activity.Tumor-targeted immune complex formation: effects on myeloid cell activation and tumor-directed immune cell migration.Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy.Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders.Multiplex bead-based measurement of humoral immune responses against tumor-associated antigens in stage II melanoma patients of the EORTC18961 trial.
P2860
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P2860
Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Renal cell carcinoma-derived g ...... r-kappaB activation in T cells
@en
type
label
Renal cell carcinoma-derived g ...... r-kappaB activation in T cells
@en
prefLabel
Renal cell carcinoma-derived g ...... r-kappaB activation in T cells
@en
P2093
P2860
P356
P1476
Renal cell carcinoma-derived g ...... r-kappaB activation in T cells
@en
P2093
A C Novick
M K Cathcart
R M Bukowski
T Hamilton
P2860
P304
P356
10.1172/JCI6775
P407
P577
1999-09-01T00:00:00Z