Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331 - Wikidata - wikimedia - TriplyDB

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

http://www.wikidata.org/entity/Q40859860

about

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates.Uracil in DNA: consequences for carcinogenesis and chemotherapy 5-Fluorouracil: mechanisms of resistance and reversal strategies.Apoptosis and molecular targeting therapy in cancer.Cellular response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs expression levels of genes involved in thymidylate metabolism.Novel opportunities for thymidylate metabolism as a therapeutic target.Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.dUTPase inhibition augments replication defects of 5-Fluorouracil.Synthesis of certain 2'-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5'; evaluation as potential dUTP analogues.Cysteine residues contribute to the dimerization and enzymatic activity of human nuclear dUTP nucleotidohydrolase (nDut)

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P2860

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

http://www.wikidata.org/entity/Q40859860

description

2000 nî lūn-bûn

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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2000年论文

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2000年论文

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Deoxyuridine triphosphatase (d ...... synthase (TS) inhibitor ZD9331

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British Journal of Cancer

P1476

Deoxyuridine triphosphatase (d ...... synthase (TS) inhibitor ZD9331

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P2093

Aherne GW

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Hardcastle A

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Jackman AL

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Ladner RD

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Webley SD

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P2860

Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase

Maturation stage and proliferation-dependent expression of dUTPase in human T cells

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase.

DNA glycosylases, endonucleases for apurinic/apyrimidinic sites, and base excision-repair.

Molecular characterisation of two cell lines selected for resistance to the folate-based thymidylate synthase inhibitor, ZD1694.

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.

Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy.

Thymineless death in colon carcinoma cells is mediated via fas signaling.

Purification and properties of the deoxyuridine triphosphate nucleotidohydrolase enzyme derived from HeLa S3 cells. Comparison to a distinct dUTP nucleotidohydrolase induced in herpes simplex virus-infected HeLa S3 cells.

Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action.

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