Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers.
about
Human recombinant endopeptidase PHEX has a strict S1' specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoproteinEndothelin-converting enzyme-like 1 (ECEL1) is present both in the plasma membrane and in the endoplasmic reticulumExtracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemiaPreosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblastsFGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralizationProteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemiaCharacterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitorsPTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4Differential regulation of PHEX expression in bone and parathyroid gland by chronic renal insufficiency and 1,25-dihydroxyvitamin D3Essential role of RSK2 in c-Fos-dependent osteosarcoma development.Genetic diagnosis of X-linked dominant Hypophosphatemic Rickets in a cohort study: tubular reabsorption of phosphate and 1,25(OH)2D serum levels are associated with PHEX mutation type.Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization.Mutational analysis of PHEX, FGF23 and DMP1 in a cohort of patients with hypophosphatemic rickets.Biomineralization of bone: a fresh view of the roles of non-collagenous proteins.An ethyl-nitrosourea-induced point mutation in phex causes exon skipping, x-linked hypophosphatemia, and rickets.Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression.A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.The wrickkened pathways of FGF23, MEPE and PHEX.Phosphate: known and potential roles during development and regeneration of teeth and supporting structures.Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin FormationOsteocyte signaling in boneEmerging role of a phosphatonin in mineral homeostasis and its derangements.Genetic Testing Confirmed the Early Diagnosis of X-Linked Hypophosphatemic Rickets in a 7-Month-Old InfantThe enigmas of bone without osteocytes.Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.Identification of differentially expressed genes between osteoblasts and osteocytes.Novel regulators of Fgf23 expression and mineralization in Hyp boneAberrant cementum phenotype associated with the hypophosphatemic hyp mouse.Seven novel and six de novo PHEX gene mutations in patients with hypophosphatemic rickets.Therapeutic management of hypophosphatemic rickets from infancy to adulthood.The phosphate regulating hormone fibroblast growth factor-23.Tooth dentin defects reflect genetic disorders affecting bone mineralization.Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.Unique roles of phosphorus in endochondral bone formation and osteocyte maturation.The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragmentTesticular acid phosphatase induces odontoblast differentiation and mineralization.MEPE has the properties of an osteoblastic phosphatonin and minhibin.Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.In vitro differentiation and mineralization of dental pulp stem cells on enamel-like fluorapatite surfaces.Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites.
P2860
Q24530025-F8D4D411-1075-447D-A0B8-1A7145FDD4EAQ24530999-CAFF7C99-6FAD-41C0-A947-606AD63DDD69Q27002346-32460339-43F9-44B1-97B8-ECE8D9A4813DQ27305468-27A48124-D14A-4012-A823-3D0569B29960Q28177435-620A7F8E-2DE0-4148-9B9A-58F7D0FFC3F6Q28275381-BE537419-72A9-4411-8EF9-0BF07BC63FE3Q28363247-1B24D502-B506-4582-90BA-91DC69AD6C4DQ28568733-67EFB7C6-1613-401D-AAFC-19609D27D5AAQ28579664-0F628DDA-383B-4045-B4BC-FE6ECEBEE01BQ33842091-A04AE168-D146-4791-A95D-6DD8C155C0C7Q34014158-1633EDBC-CFA0-440F-A0DE-4188BA9B8B25Q34503103-3F1BFAFE-58A6-4D0C-93A6-0CB2A45BFFCBQ34561127-A2D8A1BE-4F47-482A-8FA8-429BE77C7771Q35606605-F5D2F0FF-A471-4941-9FA2-F37EC442003FQ35747726-74457B29-82CB-4021-AFBC-A6B00412B078Q35762971-6070B8DA-48E0-4CA1-94A1-E9BE56A6FFC4Q35783146-B1A9D64F-0E44-4CD8-B86F-C176AC82279CQ35911345-D82A627F-9237-4366-82CD-DA2B6613260FQ35920063-CC0D4C57-C938-49FD-85EC-9C5A3B121C1EQ35932724-6E9B743C-A233-4EFF-B50F-61911EDBBB64Q36005495-69074F13-A7FC-4C72-88EE-E5482AD402DDQ36554782-FEBDB38D-790E-4F4A-A817-912CAD8A1521Q36565818-C74F752B-0E33-4B58-94CE-6659EC626F58Q36954369-238006CB-37BD-45D4-AA15-72B4045DDF4CQ37153990-C1468EF2-7338-4ED5-A2D6-A5A8627D8C07Q37316190-2A1DA18C-9360-43A7-8E5F-B99CD9096D3FQ37332408-3A079E95-0439-4BE1-B0F2-EBBC8F06BAB7Q37419525-82ECD83E-30D9-4D22-8783-6E546E5B59FBQ37426696-C5844E90-C1B5-49F9-8EA4-1B78DA76DC48Q37648693-C89559FB-72C7-42DC-90A2-94315FEE56D0Q37771349-1921272D-A46C-47C9-8300-AAB684C43EA3Q37980555-D2DBF3A3-F0DB-4EBC-88A0-04675816BAD3Q38362148-53CEA80E-4F9D-4ECC-858B-F9B671638F95Q38552814-D20F0701-0873-4B05-9E3B-615DF5FFF467Q38553300-A994BD07-847F-4F5A-8F39-1F9BC42DD5F0Q38821190-3B9B17A1-CAB7-4B33-99DD-CE346636DF27Q40590136-AD44B34B-7E5E-4A40-A946-09C041119B54Q40768048-54FA8CA5-864C-483C-8C20-698F9519137FQ41667827-0B3202C8-37B5-47AC-A846-FC2B2D5AC888Q44482171-ECD6B535-8666-47C3-9AE8-5991050FF11E
P2860
Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Developmental expression and t ...... relationship to bone markers.
@en
type
label
Developmental expression and t ...... relationship to bone markers.
@en
prefLabel
Developmental expression and t ...... relationship to bone markers.
@en
P2093
P1476
Developmental expression and t ...... d relationship to bone markers
@en
P2093
DesGroseillers L
Marcinkiewicz M
Tenenhouse HS
P2860
P304
P356
10.1359/JBMR.2000.15.8.1440
P577
2000-08-01T00:00:00Z