Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo.
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Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs)A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Modulation of cardiac contractility by the phospholamban/SERCA2a regulatomePhospholamban domain IB forms an interaction site with the loop between transmembrane helices M6 and M7 of sarco(endo)plasmic reticulum Ca2+ ATPasesStructural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR methodEnhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null miceAbnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunctionThe anti-apoptotic protein HAX-1 is a regulator of cardiac functionCardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in miceFörster transfer recovery reveals that phospholamban exchanges slowly from pentamers but rapidly from the SERCA regulatory complex.Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (review).Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylationSERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts.The mitochondrial uniporter controls fight or flight heart rate increases.A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmiaLethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.Echocardiographic characterization of the cardiovascular phenotype in rodent models.Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction.A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock.Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics.Calcium Uptake in Crude Tissue Preparation.Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbonePhospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells.Construction of phospholamban antisense RNA recombinant adeno-associated virus vector and its effects in rat cardiomyocytes.Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of Na,K-ATPase by protein kinase c via a novel member of the FXYDY family.Solid-state (2)H and (15)N NMR studies of side-chain and backbone dynamics of phospholamban in lipid bilayers: investigation of the N27A mutation.Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null miceSolid-state NMR measurements of the kinetics of the interaction between phospholamban and Ca2+-ATPase in lipid bilayersSolid-state NMR reveals structural changes in phospholamban accompanying the functional regulation of Ca2+-ATPaseNitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
P2860
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P2860
Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
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2000年學術文章
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name
Cardiac-specific overexpressio ...... n of cardiac function in vivo.
@en
type
label
Cardiac-specific overexpressio ...... n of cardiac function in vivo.
@en
prefLabel
Cardiac-specific overexpressio ...... n of cardiac function in vivo.
@en
P2093
P2860
P356
P1476
Cardiac-specific overexpressio ...... n of cardiac function in vivo.
@en
P2093
P2860
P304
10538-10544
P356
10.1074/JBC.275.14.10538
P407
P577
2000-04-01T00:00:00Z