Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

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Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML.Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia.Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice.

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Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

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2016 nî lūn-bûn

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Long-term serial xenotransplan ...... disease in Rag2-/-γc-/- mice.

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Long-term serial xenotransplan ...... disease in Rag2-/-γc-/- mice.

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Long-term serial xenotransplan ...... disease in Rag2-/-γc-/- mice.

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Long-term serial xenotransplan ...... disease in Rag2-/-γc-/- mice.

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Charlotte M Niemeyer

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Christian Flotho

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Christopher Felix Krombholz

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Daniela Bertele

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Konrad Aumann

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Matthias Kollek

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Miriam Erlacher

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Mirjam Kunze

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Silvia Fluhr

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How I treat juvenile myelomonocytic leukemia

Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)

Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

Mitotic recombination and compound-heterozygous mutations are predominant NF1-inactivating mechanisms in children with juvenile myelomonocytic leukemia and neurofibromatosis type 1.

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.

Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs.

Effect of developmental stage of HSC and recipient on transplant outcomes.

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Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

about

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P2860

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

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