Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner.
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IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine programUnderstanding the pathogenesis of Kawasaki disease by network and pathway analysisER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key PlayersThe Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavageCalpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasisCD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling.Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis.Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease.Expression profiles and function analysis of microRNAs in postovulatory aging mouse oocytes.Common variants in CASP3 confer susceptibility to Kawasaki disease.Inositol trisphosphate receptor Ca2+ release channels.Role of caspase-3 cleaved IP3 R1 on Ca(2+) homeostasis and developmental competence of mouse oocytes and eggsCaspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis.The type III inositol 1,4,5-trisphosphate receptor preferentially transmits apoptotic Ca2+ signals into mitochondria.Caffeine alleviates the deterioration of Ca(2+) release mechanisms and fragmentation of in vitro-aged mouse eggs.Calcium and apoptosis: facts and hypotheses.Variations in ORAI1 Gene Associated with Kawasaki DiseaseApoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.Changes in endoplasmic reticulum luminal environment affect cell sensitivity to apoptosis.Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis.Structural and functional link between the mitochondrial network and the endoplasmic reticulum.Apoptosis and autophagy: decoding calcium signals that mediate life or death.Cell death mechanisms and their implications in toxicology.Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.Bcl-2 proteins and calcium signaling: complexity beneath the surface.Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons.Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis.Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulationDexamethasone-induced inositol 1,4,5-trisphosphate receptor elevation in murine lymphoma cells is not required for dexamethasone-mediated calcium elevation and apoptosis.Inflammasome-mediated regulation of hepatic stellate cells.Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes.Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors.Inositol 1,4,5-trisphosphate (IP3) receptor type1 (IP3R1) modulates the acquisition of cisplatin resistance in bladder cancer cell lines.Protein Fragmentation As a Regulatory Mechanism: Insights from Two Different Ca2+ Channels, RyR1 and IP3R.
P2860
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P2860
Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Inositol 1,4,5-trisphosphate r ...... a caspase-3-dependent manner.
@en
type
label
Inositol 1,4,5-trisphosphate r ...... a caspase-3-dependent manner.
@en
prefLabel
Inositol 1,4,5-trisphosphate r ...... a caspase-3-dependent manner.
@en
P2093
P2860
P356
P1476
Inositol 1,4,5-trisphosphate r ...... a caspase-3-dependent manner.
@en
P2093
P2860
P304
34433-34437
P356
10.1074/JBC.274.48.34433
P407
P577
1999-11-01T00:00:00Z