Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase.
about
Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytesGenetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.The role of the LDL receptor in apolipoprotein B secretion.In vitro models for studying toxicity of antifungal agentsActivation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol.Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytesComparative effects of the azole-based fungicide flusilazole on yeast and mammalian lanosterol 14 alpha-methyl demethylase.Dietary fish oil-induced changes in intrahepatic cholesterol transport and bile acid synthesis in rats.Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulusCharacterization of the low-density-lipoprotein-receptor-independent interaction of beta-very-low-density lipoprotein with rat and human parenchymal liver cells in vitro.Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture.Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7alpha-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes.Uptake and degradation of human low-density lipoprotein by human liver parenchymal and Kupffer cells in culture.Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats.Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis.Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase.Differential feedback regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes.Maintenance of bile acid synthesis and cholesterol 7 alpha-hydroxylase activity in cultured rat hepatocytes.A novel nonhepatic hydroxycholesterol 7 alpha-hydroxylase that is markedly stimulated by interleukin-1 beta. Characterization in the immature rat ovary.PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.Short- and long-term effects of biliary drainage on hepatic cholesterol metabolism in the rat.Heterogeneity of rat liver parenchyma in cholesterol 7 alpha-hydroxylase and bile acid synthesis.Characterization of the inhibitory effects of bile acids on very-low-density lipoprotein secretion by rat hepatocytes in primary culture.
P2860
Q28368343-C3778894-E4BB-42F2-8480-AB6D3610E648Q33325905-4229FDB2-9065-4260-822B-DC04051AA6DCQ33939089-9181D2B9-A108-4456-AB00-E33830E4B235Q35447528-C23351DB-147B-4E6C-8D95-16C5A01C7F9CQ36688460-54E7E943-D7A1-4E0F-BC40-EC6D3CE58AEBQ37375894-1E43C5AF-6C56-4228-AEE0-486F49541FACQ39819639-699C7F1D-ED03-4CAF-9A42-F711D74FD602Q40341889-EECA1925-9AE7-45D5-8124-38F9846B14B9Q41010263-CCD6D747-0E5A-40C2-8370-AC836D11035CQ41639851-B892689F-C765-4AAA-B869-7B29C6511806Q41667058-6864F3CF-8D07-40FD-A127-C750C7E918A0Q41815968-42487237-6DD8-41A5-87A9-8A607936743DQ41839071-627E5595-4975-442C-9963-74569590B21FQ41976615-37080F31-D5A1-4A89-8361-6BDE1BA75A26Q42023326-BB34B9D1-AB21-4E90-9DD9-12812288A5FAQ42122547-96EF26CF-61D0-46A0-A33B-32203940E3D9Q42161320-CE61F75E-7EFD-4F3E-ABC4-04615631D77CQ42183230-02F06BD4-2425-431C-9E94-3704B5047C6FQ42481640-A498B9EF-98E9-4D9A-8C98-89EB05EF01C1Q42747711-FED8FE0C-9C18-4FAB-B4F8-2A8653679FD6Q42794879-1EF85CAE-E632-460E-B938-C10E8DB78D7EQ42797114-46650BDE-3326-4226-BF0D-6EAFB1FF49BDQ42982452-30C7642C-E988-4447-B844-2CAA0480AACE
P2860
Ketoconazole blocks bile acid synthesis in hepatocyte monolayer cultures and in vivo in rat by inhibiting cholesterol 7 alpha-hydroxylase.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh
1986年學術文章
@zh-hant
name
Ketoconazole blocks bile acid ...... olesterol 7 alpha-hydroxylase.
@en
type
label
Ketoconazole blocks bile acid ...... olesterol 7 alpha-hydroxylase.
@en
prefLabel
Ketoconazole blocks bile acid ...... olesterol 7 alpha-hydroxylase.
@en
P2093
P2860
P356
P1476
Ketoconazole blocks bile acid ...... olesterol 7 alpha-hydroxylase.
@en
P2093
C M Huijsmans
H J Kempen
H M Princen
P2860
P304
P356
10.1172/JCI112662
P407
P577
1986-10-01T00:00:00Z