Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein.
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Characterization of the DNA binding specificity of Shelterin complexesTwenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward?The splicing factor U1C represses EWS/FLI-mediated transactivationOff-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2Overexpression of Fli-1 in astrocytoma is associated with poor prognosis.Effect of antisense human telomerase RNA on malignant phenotypes of gastric carcinoma.Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro.Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.Telomerase activation without shortening of telomeric 3'-overhang is a poor prognostic factor in human colorectal cancer.Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitorsTelomere Biology-Insights into an Intriguing Phenomenon.Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.The TET family of proteins: functions and roles in disease.RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.Cell Cycle Deregulation in Ewing's Sarcoma PathogenesisEpigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomasReview of therapeutic strategies for osteosarcoma, chondrosarcoma, and Ewing's sarcoma.BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcomaLysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells.Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.Ewing's sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities.BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.Promiscuous partnerships in Ewing's sarcoma.3D tissue-engineered model of Ewing's sarcomaElucidating the mechanism of regulation of transforming growth factor β Type II receptor expression in human lung cancer cell linesTranscription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis.PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1.Resistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell lymphoma cell lines.Targeted therapy in Ewing sarcoma.Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil.Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanismEwing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.The biology of ewing sarcomaRecent advances in the molecular pathogenesis of Ewing's sarcoma.Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.Microsatellite instability in sarcoma: fact or fiction?Microsatellites as EWS/FLI response elements in Ewing's sarcoma
P2860
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P2860
Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Repression of the gene encodin ...... t of the EWS-FLI1 oncoprotein.
@en
type
label
Repression of the gene encodin ...... t of the EWS-FLI1 oncoprotein.
@en
prefLabel
Repression of the gene encodin ...... t of the EWS-FLI1 oncoprotein.
@en
P2093
P356
P1433
P1476
Repression of the gene encodin ...... t of the EWS-FLI1 oncoprotein.
@en
P2093
Sorensen PH
P304
P356
10.1038/13854
P407
P577
1999-10-01T00:00:00Z
P6179
1041243219