Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
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Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vectorExpression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriersGeneration of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation.Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors.Adenovirus-mediated in vivo silencing of anaphylatoxin receptor C5aR.Fiber and penton base capsid modifications yield diminished adenovirus type 5 transduction and proinflammatory gene expression with retention of antigen-specific humoral immunity.The transduction of Coxsackie and Adenovirus Receptor-negative cells and protection against neutralizing antibodies by HPMA-co-oligolysine copolymer-coated adenovirusSuppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells.The expression of exogenous genes in macrophages: obstacles and opportunities.Specific and efficient targeting of adenovirus vectors to macrophages: application of a fusion protein between an adenovirus-binding fragment and avidin, linked to a biotinylated oligonucleotide.Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors.Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection.Genetically modified adenoviral vector with the protein transduction domain of Tat improves gene transfer to CAR-deficient cells.Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines.Infectivity enhanced, hTERT promoter-based conditionally replicative adenoviruses are useful for SCLC treatment.Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.Coxsackie and adenovirus receptor (CAR)-dependent and major histocompatibility complex (MHC) class I-independent uptake of recombinant adenoviruses into human tumour cells.Cytokine-mediated downregulation of coxsackievirus-adenovirus receptor in endothelial cells.Inhibition of porcine reproductive and respiratory syndrome virus infection by recombinant adenovirus- and/or exosome-delivered the artificial microRNAs targeting sialoadhesin and CD163 receptorsThe size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer.The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer.Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver disease.Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells.Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes.Infection efficiency of type 5 adenoviral vectors in synovial tissue can be enhanced with a type 16 fiber.Adenoviral vectors transduce alveolar macrophages in lung cancer models.
P2860
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P2860
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Modification of the genetic pr ...... coxsackie/adenovirus receptor.
@en
type
label
Modification of the genetic pr ...... coxsackie/adenovirus receptor.
@en
prefLabel
Modification of the genetic pr ...... coxsackie/adenovirus receptor.
@en
P2093
P2860
P356
P1476
Modification of the genetic pr ...... coxsackie/adenovirus receptor.
@en
P2093
Bergelson J
Crystal RG
Falck-Pedersen E
Hackett NR
Leopold PL
Ramalingam R
P2860
P304
P356
10.1165/AJRCMB.20.3.3398
P577
1999-03-01T00:00:00Z