A proportion of proteinase 3 (PR3)-specific anti-neutrophil cytoplasmic antibodies (ANCA) only react with PR3 after cleavage of its N-terminal activation dipeptide.
about
What you should know about PR3-ANCA. Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA.Autoantibodies in vasculitisMethods for the detection of anti-neutrophil cytoplasmic antibodies. Recommendations for clinical use of ANCA serology and laboratory efforts to optimize the informative value of ANCA test results.Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosisB cell epitope specificity in ANCA-associated vasculitis: does it matter?A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism.Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments.A study of conformational restraints on reactivity of human PR3-specific autoantibodies (ANCA) facilitated through protein folding manipulations of a new recombinant proteinase 3 protein.
P2860
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P2860
A proportion of proteinase 3 (PR3)-specific anti-neutrophil cytoplasmic antibodies (ANCA) only react with PR3 after cleavage of its N-terminal activation dipeptide.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
A proportion of proteinase 3 ( ...... terminal activation dipeptide.
@en
type
label
A proportion of proteinase 3 ( ...... terminal activation dipeptide.
@en
prefLabel
A proportion of proteinase 3 ( ...... terminal activation dipeptide.
@en
P2093
P2860
P1476
A proportion of proteinase 3 ( ...... terminal activation dipeptide.
@en
P2093
Homburger HA
P2860
P304
P356
10.1046/J.1365-2249.1998.00730.X
P577
1998-11-01T00:00:00Z