Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase
about
Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transductionInsulin receptor signaling in normal and insulin-resistant statesThe Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of ObesityRole of auxin-induced reactive oxygen species in root gravitropismSemicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cellsTumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversionInsulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxideMitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neuronsT cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulationIncreased oxidative stress in obesity and its impact on metabolic syndromeInsulin: new roles for an ancient hormone.Statins in the treatment of polycystic ovary syndrome.Activation and attenuation of transcription factor NF-kB in mouse glomerular mesangial cells in response to tumor necrosis factor-alpha, immunoglobulin G, and adenosine 3':5'-cyclic monophosphate. Evidence for involvement of reactive oxygen species.Cardiovascular impact of drugs used in the treatment of diabetesOxidative stress as a mechanism of added sugar-induced cardiovascular disease.Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targetsDownregulation of STEAP4, a highly-expressed TNF-alpha-inducible gene in adipose tissue, is associated with obesity in humans.Redox regulation of protein kinases.Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytesInsulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species.Reactive oxygen species-mediated signal transduction in the endothelium.NOX4 pathway as a source of selective insulin resistance and responsivenessRole of insulin-induced reactive oxygen species in the insulin signaling pathwayMitochondria, oxidative DNA damage, and agingHydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction.Leptin regulation of Hsp60 impacts hypothalamic insulin signalingH2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria.Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases.Roles of oxidative stress, adiponectin, and nuclear hormone receptors in obesity-associated insulin resistance and cardiovascular risk.Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management.Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats.Hydrogen peroxide-induced translocation of glycolipid-anchored (c)AMP-hydrolases to lipid droplets mediates inhibition of lipolysis in rat adipocytes.Insulin signaling is inhibited by micromolar concentrations of H(2)O(2). Evidence for a role of H(2)O(2) in tumor necrosis factor alpha-mediated insulin resistance.Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide.Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells.The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines.Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis.Putative role of proteins involved in detoxification of reactive oxygen species in the early response to gravitropic stimulation of poplar stems.
P2860
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P2860
Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Human fat cells possess a plas ...... bypassing the receptor kinase
@en
type
label
Human fat cells possess a plas ...... bypassing the receptor kinase
@en
prefLabel
Human fat cells possess a plas ...... bypassing the receptor kinase
@en
P2860
P356
P1476
Human fat cells possess a plas ...... bypassing the receptor kinase
@en
P2093
Krieger-Brauer HI
P2860
P304
P356
10.1172/JCI115641
P407
P577
1992-03-01T00:00:00Z